Adverse prognostic factors in adult acute lymphocytic leukemia (ALL).*
| * Adverse prognostic factors as they emerged from the more than 3000 adult ALL patients treated in the GMALL (German Multicenter Studies for Adult ALL) trials.24,25 | |
| Clinical characteristics | Higher age: > 50 yrs, > 60 yrs |
| High WBC: > 300,00/μl in B-lineage | |
| Immunophenotype | Pro B (B-lin., CD10) |
| Early T (T-lin., CD1a, sCD3) | |
| Mature T (T-lin., CD1a, sCD3+) | |
| Cytogenetics/molecular genetics | t(9;22)/BCR-ABL or t(4;11)/ALL1-AF4 |
| Treatment response | Late achievement of CR: > 3, 4 weeks |
| MRD positivity | |
| * Adverse prognostic factors as they emerged from the more than 3000 adult ALL patients treated in the GMALL (German Multicenter Studies for Adult ALL) trials.24,25 | |
| Clinical characteristics | Higher age: > 50 yrs, > 60 yrs |
| High WBC: > 300,00/μl in B-lineage | |
| Immunophenotype | Pro B (B-lin., CD10) |
| Early T (T-lin., CD1a, sCD3) | |
| Mature T (T-lin., CD1a, sCD3+) | |
| Cytogenetics/molecular genetics | t(9;22)/BCR-ABL or t(4;11)/ALL1-AF4 |
| Treatment response | Late achievement of CR: > 3, 4 weeks |
| MRD positivity | |