Response criteria in chronic myelogenous leukemia (CML).
| Response . | Definition . |
|---|---|
| Complete hematologic response | Normalization of the peripheral blood with WBC <10 x 109/L with no immature forms, normal platelet count, and disappearance of all signs and symptoms of the disease |
| Partial hematologic response | As above, but persistent immature peripheral cells (blasts, promyelocytes, myelocytes), persistent splenomegaly or thombocytosis, but ≥ 50% reduction. |
| Complete cytogenetic response | 0% Ph+ metaphases on cytogenetic analysis |
| Partial cytogenetic response | 1-35% Ph+ metaphases on cytogenetic analysis |
| Minor cytogenetic response | 35-95% Ph+ metaphases on cytogenetic analysis |
| Response . | Definition . |
|---|---|
| Complete hematologic response | Normalization of the peripheral blood with WBC <10 x 109/L with no immature forms, normal platelet count, and disappearance of all signs and symptoms of the disease |
| Partial hematologic response | As above, but persistent immature peripheral cells (blasts, promyelocytes, myelocytes), persistent splenomegaly or thombocytosis, but ≥ 50% reduction. |
| Complete cytogenetic response | 0% Ph+ metaphases on cytogenetic analysis |
| Partial cytogenetic response | 1-35% Ph+ metaphases on cytogenetic analysis |
| Minor cytogenetic response | 35-95% Ph+ metaphases on cytogenetic analysis |