Results of nonmyeloablative HLA-identical sibling transplantation for sickle cell anemia. (Iannone et al, August 2002, unpublished data).40- 43
| Regimen . | Minimal-Toxicity Conditioning Regimen . | Reduced-Intensity Conditioning . |
|---|---|---|
| †Includes 2 patients with thalassemia major. | ||
| ‡Includes 1 patient with thalassemia major. | ||
| Abbreviations: ATG, antithymocyte globulin; CY, cyclophosphamide; Flu, fludarabine; Gr, grade; GVHD, graft-versus-host disease; Mel, melphalan; No., number; PBSC, peripheral blood stem cells; TBI, total body irradiation; TLI, total lymphoid irradiation; UCB, umbilical cord blood. | ||
| No. of patients | 10† | 7‡ |
| Patient age (median, yrs) | 10 (range, 3-28) | 22 (range, 7-56) |
| Conditioning regimen (dose) [no. of patients] | Flu (90-150)/TBI (200) [5]; Flu (125-150)/ATG/TBI (200)[5] | Flu(175)/BU(8)/ATG/TLI (500)[4]; Flu (120)/Mel(140)/ATG [2]; Flu(120)/ CY(120) [1] |
| Source of stem cells (no. of patients) | Marrow (8); PBSC (2) | Marrow (2); PBSC (3); UCB (1) |
| Induction of mixed chimerism | Yes (transient in 8) | Yes |
| No. with graft rejection/disease recurrence | 8 | 1 |
| No. with GVHD | Acute 1 (Gr I), chronic, none | Acute 3 (Gr II-IV), chronic, 3 (2 fatal) |
| No. of deaths | None | 2 |
| No. with event-free survival | 2 | 4 |
| Regimen . | Minimal-Toxicity Conditioning Regimen . | Reduced-Intensity Conditioning . |
|---|---|---|
| †Includes 2 patients with thalassemia major. | ||
| ‡Includes 1 patient with thalassemia major. | ||
| Abbreviations: ATG, antithymocyte globulin; CY, cyclophosphamide; Flu, fludarabine; Gr, grade; GVHD, graft-versus-host disease; Mel, melphalan; No., number; PBSC, peripheral blood stem cells; TBI, total body irradiation; TLI, total lymphoid irradiation; UCB, umbilical cord blood. | ||
| No. of patients | 10† | 7‡ |
| Patient age (median, yrs) | 10 (range, 3-28) | 22 (range, 7-56) |
| Conditioning regimen (dose) [no. of patients] | Flu (90-150)/TBI (200) [5]; Flu (125-150)/ATG/TBI (200)[5] | Flu(175)/BU(8)/ATG/TLI (500)[4]; Flu (120)/Mel(140)/ATG [2]; Flu(120)/ CY(120) [1] |
| Source of stem cells (no. of patients) | Marrow (8); PBSC (2) | Marrow (2); PBSC (3); UCB (1) |
| Induction of mixed chimerism | Yes (transient in 8) | Yes |
| No. with graft rejection/disease recurrence | 8 | 1 |
| No. with GVHD | Acute 1 (Gr I), chronic, none | Acute 3 (Gr II-IV), chronic, 3 (2 fatal) |
| No. of deaths | None | 2 |
| No. with event-free survival | 2 | 4 |