Indications for transplantation for sickle cell disease.
| Current Inclusion Criteria . |
|---|
| Abbreviations: CNS, central nervous system; GFR, glomerular filtration rate; MRI, magnetic resonance imaging; RBC, red blood cell. |
| Patients with sickle cell disease (SS or Sβ°-thalassemia) less than 16 years of age |
| One or more of the following complications: |
| Stroke or CNS event lasting longer than 24 hours |
| Recurrent acute chest syndrome |
| Recurrent vaso-occlusive painful episodes or recurrent priapism |
| Impaired neuropsychologic function with abnormal cerebral MRI and angiography |
| Other Considerations for Inclusion Criteria |
| Stage I or II sickle lung disease |
| Sickle nephropathy (GFR 30-50% of predicted normal) |
| Osteonecrosis of multiple joints |
| RBC alloimmunization (≥2 antibodies) on chronic transfusion therapy |
| Increased cerebral arterial velocity by transcranial doppler |
| Current Inclusion Criteria . |
|---|
| Abbreviations: CNS, central nervous system; GFR, glomerular filtration rate; MRI, magnetic resonance imaging; RBC, red blood cell. |
| Patients with sickle cell disease (SS or Sβ°-thalassemia) less than 16 years of age |
| One or more of the following complications: |
| Stroke or CNS event lasting longer than 24 hours |
| Recurrent acute chest syndrome |
| Recurrent vaso-occlusive painful episodes or recurrent priapism |
| Impaired neuropsychologic function with abnormal cerebral MRI and angiography |
| Other Considerations for Inclusion Criteria |
| Stage I or II sickle lung disease |
| Sickle nephropathy (GFR 30-50% of predicted normal) |
| Osteonecrosis of multiple joints |
| RBC alloimmunization (≥2 antibodies) on chronic transfusion therapy |
| Increased cerebral arterial velocity by transcranial doppler |