Clinicopathological classification of chronic graft-versus-host disease (GVHD).
| Reprinted with permission from Sullivan KM. Graft-versus-host disease. In: Thomas ED, Blume KG, Forman SJ, ed. Hematopoietic Cell Transplantation (ed 2nd). Malden, MA: Blackwell Science, Inc.; 1999:515-536. |
| Limited Chronic GVHD |
| Either or both: |
| 1. Localized skin involvement |
| 2. Hepatic dysfunction due to chronic GVHD |
| Extensive Chronic GVHD |
| Either: |
| 1. Generalized skin involvement, or |
| 2. Localized skin involvement and/or hepatic dysfunction due to chronic GVHD |
| Plus: |
| 3a. Liver histology showing chronic aggressive hepatitis, bridging necrosis, or cirrhosis, or |
| 3b. Involvement of eye (Schirmer test with < 5 mm wetting), or |
| 3c. Involvement of minor salivary glands or oral mucosa demonstrated on labial biopsy, or |
| 3d. Involvement of any other target organ |
| Reprinted with permission from Sullivan KM. Graft-versus-host disease. In: Thomas ED, Blume KG, Forman SJ, ed. Hematopoietic Cell Transplantation (ed 2nd). Malden, MA: Blackwell Science, Inc.; 1999:515-536. |
| Limited Chronic GVHD |
| Either or both: |
| 1. Localized skin involvement |
| 2. Hepatic dysfunction due to chronic GVHD |
| Extensive Chronic GVHD |
| Either: |
| 1. Generalized skin involvement, or |
| 2. Localized skin involvement and/or hepatic dysfunction due to chronic GVHD |
| Plus: |
| 3a. Liver histology showing chronic aggressive hepatitis, bridging necrosis, or cirrhosis, or |
| 3b. Involvement of eye (Schirmer test with < 5 mm wetting), or |
| 3c. Involvement of minor salivary glands or oral mucosa demonstrated on labial biopsy, or |
| 3d. Involvement of any other target organ |