Genes shared and distinctive between MLL translocation variants (MLL/ALL1/HRX gene on chromosome 11q23) in acute myeloid leukemia (AML)/acute lymphoblastic leukemia (ALL).
| Genes Shared in All MLL Variants . | t(4;11) . | t(11;19) . | t(9;11) . | t(10;11) . |
|---|---|---|---|---|
| † FLT3 expression is more significantly associated with t(4;11) than with all MLL variants. | ||||
| Lyn | Bmi-1 | HRAFY | TRADD | RUNX3 |
| NFATC3 | DOK1 | ERH | TCFL4 | HMGCR |
| RAD9 | WAS | IL2Rγ | COX7 | HGF |
| CD44 | PPKAR | IRAK1 | HSF1 | CDKN1CD |
| AC133 | YES | IGBP1 | AHR | RARα |
| BAG1 | TIMP1 | TACT | PLCγ2 | RARES2 |
| CRADD | ELF4 | LPXN | Rab33A | TNFSF9 |
| Blk | JUND | Serpine | RASA1 | GIT2 |
| FLT3† | FLT3† | MAGED2 | DOC1R | SH3BP1 |
| Genes Shared in All MLL Variants . | t(4;11) . | t(11;19) . | t(9;11) . | t(10;11) . |
|---|---|---|---|---|
| † FLT3 expression is more significantly associated with t(4;11) than with all MLL variants. | ||||
| Lyn | Bmi-1 | HRAFY | TRADD | RUNX3 |
| NFATC3 | DOK1 | ERH | TCFL4 | HMGCR |
| RAD9 | WAS | IL2Rγ | COX7 | HGF |
| CD44 | PPKAR | IRAK1 | HSF1 | CDKN1CD |
| AC133 | YES | IGBP1 | AHR | RARα |
| BAG1 | TIMP1 | TACT | PLCγ2 | RARES2 |
| CRADD | ELF4 | LPXN | Rab33A | TNFSF9 |
| Blk | JUND | Serpine | RASA1 | GIT2 |
| FLT3† | FLT3† | MAGED2 | DOC1R | SH3BP1 |