Adhesion molecule interactions.
| Adhesion Molecule . | Location . | Ligand . | Location . |
|---|---|---|---|
| Abbreviations: VLA, very late antigen; HP, hematopoietic progenitors; AML, acute myeloid leukemia; VCAM, vascular adhesion molecule; ECM, extracellular matrix; MSC, marrow stromal cells; LFA, lymphocyte function antigen; DHC, differentiated hematopoietic cells; ICAM, intercellular adhesion molecule; EC, endothelial cells. | |||
| β1 integrins | |||
| α4β1 (VLA-4) | HP | Fibronectin (CS1 domain) | ECM |
| AML cells | VCAM-1 | MSC | |
| α5β1 (VLA-5) | HP | Fibronectin (RGD sequence) | ECM |
| β2 integrins | |||
| LFA-1 | HP, AML cells | ICAM-1 | MSC, EC |
| Mac-1 | DHC, AML cells | ||
| Selectins | |||
| E-selectin | EC | Sialylated sugar moieties; Lewis x; CD44 | Myeloid cells, T cells |
| P-selectin | EC, platelets | P selectin, glycoprotein ligand 1 (CD162) | Myeloid cells, AML blasts |
| L-selectin | HP | Glycoprotein ligand | HP, AML blasts |
| CD44 | HP | Hyaluronic acid | ECM |
| AML blasts | Fibronectin | ||
| Adhesion Molecule . | Location . | Ligand . | Location . |
|---|---|---|---|
| Abbreviations: VLA, very late antigen; HP, hematopoietic progenitors; AML, acute myeloid leukemia; VCAM, vascular adhesion molecule; ECM, extracellular matrix; MSC, marrow stromal cells; LFA, lymphocyte function antigen; DHC, differentiated hematopoietic cells; ICAM, intercellular adhesion molecule; EC, endothelial cells. | |||
| β1 integrins | |||
| α4β1 (VLA-4) | HP | Fibronectin (CS1 domain) | ECM |
| AML cells | VCAM-1 | MSC | |
| α5β1 (VLA-5) | HP | Fibronectin (RGD sequence) | ECM |
| β2 integrins | |||
| LFA-1 | HP, AML cells | ICAM-1 | MSC, EC |
| Mac-1 | DHC, AML cells | ||
| Selectins | |||
| E-selectin | EC | Sialylated sugar moieties; Lewis x; CD44 | Myeloid cells, T cells |
| P-selectin | EC, platelets | P selectin, glycoprotein ligand 1 (CD162) | Myeloid cells, AML blasts |
| L-selectin | HP | Glycoprotein ligand | HP, AML blasts |
| CD44 | HP | Hyaluronic acid | ECM |
| AML blasts | Fibronectin | ||