Selected clinical trial results with fludarabine in previously untreated chronic lymphocytic leukemia (CLL) patients.
| Ref . | Regimen . | Phase . | No. Pts . | CR . | ORR . | Mean PFS (mo) . | Mean OS (mo) . |
|---|---|---|---|---|---|---|---|
| Abbreviations: Ref, reference; No, number; Flu, fludarabine; CAP, cyclophosphamide, adriamycin, prednisone; CLB, chlorambucil; CHOP—cyclophosphamide, adriamycin, vincristine, prednisone; Cy, cyclophosphamide; Ritux, rituximab; CR, complete response rate; ORR, overall response rate; PFS, progression free survival; OS, overall survival; NR, not reached; Not Rep, not reported. | |||||||
| 27 | Flu versus | III | 52 | 23 | 71 | NR | NR |
| CAP | 48 | 17 | 60 | 7 | 54 | ||
| 28 | Flu versus | III | 170 | 20 | 63 | 20 | 66 |
| CLB versus | 181 | 4 | 37 | 14 | 56 | ||
| Flu + CLB | 123 | 20 | 61 | Not Rep | 55 | ||
| 29 | Flu versus | III | 341 | 40 | 71 | 32 | 69 |
| CHOP versus | 357 | 30 | 72 | 30 | 67 | ||
| CAP | 237 | 15 | 58 | 28 | 70 | ||
| 37 | Flu + Cy | II | 17 | 51 | 92 | Not Rep | Not Rep |
| 38 | Flu + Cy | II | 34 | 35 | 88 | NR | NR |
| 39 | Flu + Cy | II | 36 | 42 | 64 | Not Rep | Not Rep |
| 40 | Flu + Cy | II | 59 | 47 | 78 | Not Rep | Not Rep |
| 51 | Flu + Ritux versus | II | 51 | 47 | 90 | NR | NR |
| Flu then Ritux | 53 | 28 | 77 | NR | NR | ||
| 52 | Flu + Cy + Ritux | II | 60 | 66 | 95 | NR | NR |
| Ref . | Regimen . | Phase . | No. Pts . | CR . | ORR . | Mean PFS (mo) . | Mean OS (mo) . |
|---|---|---|---|---|---|---|---|
| Abbreviations: Ref, reference; No, number; Flu, fludarabine; CAP, cyclophosphamide, adriamycin, prednisone; CLB, chlorambucil; CHOP—cyclophosphamide, adriamycin, vincristine, prednisone; Cy, cyclophosphamide; Ritux, rituximab; CR, complete response rate; ORR, overall response rate; PFS, progression free survival; OS, overall survival; NR, not reached; Not Rep, not reported. | |||||||
| 27 | Flu versus | III | 52 | 23 | 71 | NR | NR |
| CAP | 48 | 17 | 60 | 7 | 54 | ||
| 28 | Flu versus | III | 170 | 20 | 63 | 20 | 66 |
| CLB versus | 181 | 4 | 37 | 14 | 56 | ||
| Flu + CLB | 123 | 20 | 61 | Not Rep | 55 | ||
| 29 | Flu versus | III | 341 | 40 | 71 | 32 | 69 |
| CHOP versus | 357 | 30 | 72 | 30 | 67 | ||
| CAP | 237 | 15 | 58 | 28 | 70 | ||
| 37 | Flu + Cy | II | 17 | 51 | 92 | Not Rep | Not Rep |
| 38 | Flu + Cy | II | 34 | 35 | 88 | NR | NR |
| 39 | Flu + Cy | II | 36 | 42 | 64 | Not Rep | Not Rep |
| 40 | Flu + Cy | II | 59 | 47 | 78 | Not Rep | Not Rep |
| 51 | Flu + Ritux versus | II | 51 | 47 | 90 | NR | NR |
| Flu then Ritux | 53 | 28 | 77 | NR | NR | ||
| 52 | Flu + Cy + Ritux | II | 60 | 66 | 95 | NR | NR |