Comparison of purified clonal CD5+/CD19+ versus fluorescence in situ hybridization (FISH) anomalies in eight patients with stable disease.*
Patient . | Genetic Anomaly† . | CD5+/CD19+, %* . | Abnormal FISH Nuclei, % . | Delta‡ . |
---|---|---|---|---|
* CD5+/CD19+ cells were sorted by magnetic bead methods, and their purity was confirmed by flow cytometry. | ||||
†Two anomalies are indicated by a “/” meaning that 1 clone has both genetic defects. | ||||
‡Delta is difference between percentage of purified clonal CLL B cells and numbers of FISH abnormal cells. | ||||
1 | 11q/13q | 98 | 70/92 | 28/6 |
2 | 13q | 99 | 92 | 7 |
3 | 13q | 97 | 89 | 8 |
4 | 13q | 96 | 83 | 13 |
5 | +12/17p | 98 | 59/71 | 39/27 |
6 | +12 | 99 | 65 | 34 |
7 | 13q | 95 | 40 | 55 |
8 | 13q | 96 | 23 | 73 |
Patient . | Genetic Anomaly† . | CD5+/CD19+, %* . | Abnormal FISH Nuclei, % . | Delta‡ . |
---|---|---|---|---|
* CD5+/CD19+ cells were sorted by magnetic bead methods, and their purity was confirmed by flow cytometry. | ||||
†Two anomalies are indicated by a “/” meaning that 1 clone has both genetic defects. | ||||
‡Delta is difference between percentage of purified clonal CLL B cells and numbers of FISH abnormal cells. | ||||
1 | 11q/13q | 98 | 70/92 | 28/6 |
2 | 13q | 99 | 92 | 7 |
3 | 13q | 97 | 89 | 8 |
4 | 13q | 96 | 83 | 13 |
5 | +12/17p | 98 | 59/71 | 39/27 |
6 | +12 | 99 | 65 | 34 |
7 | 13q | 95 | 40 | 55 |
8 | 13q | 96 | 23 | 73 |