Summary of B-cell chronic lymphocytic leukemia (B-CLL) panel fluorescence in situ hybridization (FISH) test.
| Probes (Chromosome Locus) . | Upper Limit of Normal Ranges, %† . | ||||
|---|---|---|---|---|---|
| Genetic Anomaly . | Spectrum Orange . | Spectrum Green . | Deletion . | Trisomy . | Translocation . |
| Abbreviations: NA, not applicable. | |||||
| †Based on analysis of blood from 20 normal individuals and a one-sided 95% confidence interval for observing the maximum number of nuclei for each false-positive signal pattern seen in 200 scorable nuclei using the binomial distribution. | |||||
| 6q | C-MYB (6q23) | D6Z1 (6 centromere) | 6.5 | 1.5 | NA |
| 11q | ATM (11q23) | D11Z1 (11 centromere) | 5.0 | 1.5 | NA |
| +12 | D12Z3 (12 centromere) | MDM2 (12q15) | 7.5 | 1.5 | NA |
| 13q-x1 | D13S319 (13q14) | D13S327 (13qter) | 7.0 | 5.0 | NA |
| 13q-x2 | D13S319 (13q14) | D13S327 (13qter) | 1.5 | 5.0 | NA |
| 17p | P53 (17p13.1) | D17Z1 (17 centromere) | 8.5 | 1.5 | NA |
| t(11;14) | CCND1 (11q13) | IgH (14q32) | NA | NA | 2.5 |
| Probes (Chromosome Locus) . | Upper Limit of Normal Ranges, %† . | ||||
|---|---|---|---|---|---|
| Genetic Anomaly . | Spectrum Orange . | Spectrum Green . | Deletion . | Trisomy . | Translocation . |
| Abbreviations: NA, not applicable. | |||||
| †Based on analysis of blood from 20 normal individuals and a one-sided 95% confidence interval for observing the maximum number of nuclei for each false-positive signal pattern seen in 200 scorable nuclei using the binomial distribution. | |||||
| 6q | C-MYB (6q23) | D6Z1 (6 centromere) | 6.5 | 1.5 | NA |
| 11q | ATM (11q23) | D11Z1 (11 centromere) | 5.0 | 1.5 | NA |
| +12 | D12Z3 (12 centromere) | MDM2 (12q15) | 7.5 | 1.5 | NA |
| 13q-x1 | D13S319 (13q14) | D13S327 (13qter) | 7.0 | 5.0 | NA |
| 13q-x2 | D13S319 (13q14) | D13S327 (13qter) | 1.5 | 5.0 | NA |
| 17p | P53 (17p13.1) | D17Z1 (17 centromere) | 8.5 | 1.5 | NA |
| t(11;14) | CCND1 (11q13) | IgH (14q32) | NA | NA | 2.5 |