Selected pharmacologic features of voriconazole and posaconazole.
| . | Voriconazole . | Posaconazole . |
|---|---|---|
| Abbreviations: CSF, cerebrospinal fluid | ||
| T ½ (hrs) | 6 | 25 |
| % protein binding | 65% | >90% |
| Metabolism | Hepatic | Hepatic |
| Oral bioavailability | 90% | 35% |
| CSF / serum | 50% | <1% |
| Urine / serum | 5% | <1% |
| Administration | p.o. / i.v. | p.o. |
| . | Voriconazole . | Posaconazole . |
|---|---|---|
| Abbreviations: CSF, cerebrospinal fluid | ||
| T ½ (hrs) | 6 | 25 |
| % protein binding | 65% | >90% |
| Metabolism | Hepatic | Hepatic |
| Oral bioavailability | 90% | 35% |
| CSF / serum | 50% | <1% |
| Urine / serum | 5% | <1% |
| Administration | p.o. / i.v. | p.o. |