Comparison of the main results of the French45 and the Italian50 studies of α-interferon (IFN-α) + low dose cytosine arabinoside (LDAC) versus IFN-α alone. A difference in favor of IFN-α + LDAC was confirmed for major cytogenetic response (Ph neg 66-100%), but not for overall survival.
| . | French study (n = 721) . | Italian study (n = 538) . | ||||
|---|---|---|---|---|---|---|
| . | IFN-α + LDAC . | IFN-α . | P . | IFN-α + LDAC . | IFN-α . | P . |
| Abbreviations: NR, not reported | ||||||
| Complete hematologic response at 6 months | 66% | 55% | 0.003 | 62% | 55% | 0.11 |
| Major cytogenetic response (Ph neg 66-100%) at 12 months | 35% | 21% | 0.001 | 21% | 13% | 0.012 |
| Major cytogenetic response (Ph neg 66-100%) at 24 months | NR | NR | 28% | 18% | 0.003 | |
| 5-year survival | 70% | 62% | 0.02 | 68% | 65% | 0.77 |
| . | French study (n = 721) . | Italian study (n = 538) . | ||||
|---|---|---|---|---|---|---|
| . | IFN-α + LDAC . | IFN-α . | P . | IFN-α + LDAC . | IFN-α . | P . |
| Abbreviations: NR, not reported | ||||||
| Complete hematologic response at 6 months | 66% | 55% | 0.003 | 62% | 55% | 0.11 |
| Major cytogenetic response (Ph neg 66-100%) at 12 months | 35% | 21% | 0.001 | 21% | 13% | 0.012 |
| Major cytogenetic response (Ph neg 66-100%) at 24 months | NR | NR | 28% | 18% | 0.003 | |
| 5-year survival | 70% | 62% | 0.02 | 68% | 65% | 0.77 |