Dose-response to STI571.
| Dose of STI571 . | Complete Hematologic Response . | Marrow Response . | Cytogenetic Response . |
|---|---|---|---|
| Data are from the phase I clinical trial of STI571 in chronic phase CML patients who failed therapy with interferon.3 Marrow response means return of marrow morphology to normal. Cytogenetic response requires less than 65% Ph positive metaphases. | |||
| 200 mg | 3/9 (33%) | 1/9 (11%) | 1/9 (11%) |
| 250 mg | 4/7 (57%) | 2/7 (28%) | 1/7 (14%) |
| > 300 mg | 53/54 (98%) | > 80% | 29/54 (53%) |
| Dose of STI571 . | Complete Hematologic Response . | Marrow Response . | Cytogenetic Response . |
|---|---|---|---|
| Data are from the phase I clinical trial of STI571 in chronic phase CML patients who failed therapy with interferon.3 Marrow response means return of marrow morphology to normal. Cytogenetic response requires less than 65% Ph positive metaphases. | |||
| 200 mg | 3/9 (33%) | 1/9 (11%) | 1/9 (11%) |
| 250 mg | 4/7 (57%) | 2/7 (28%) | 1/7 (14%) |
| > 300 mg | 53/54 (98%) | > 80% | 29/54 (53%) |