Table 4.

Lab abnormalities.

Myeloid blast crisisAccelerated phaseChronic phase, interferon failure
n = 260n = 235n = 532
(%)(%)(%)
Grade 3Grade 4Grade 3Grade 4Grade 3Grade 4
CTC grades: neutropenia (grade 3 ≥ 0.5 – 1.0 x 109/L, grade 4 < 0.5 x 109/L), thrombocytopenia (grade 3 ≥ 10 – 50 x 109/L, grade 4 < 10 x 109/L), anemia (hemoglobin ≥ 65 – 80 g/L, grade 4 < 65 g/L), elevated creatinine (grade 3 > 3-6 x upper limit normal range (ULN), grade 4 > 6 x ULN), elevated bilirubin (grade 3 > 3-10 x ULN, grade 4 > 10 x ULN), elevated alkaline phosphatase (grade 3 > 5-20 x ULN, grade 4 > 20 x ULN), elevated SGOT or SGPT (grade 3 > 5-20 x ULN, grade 4 > 20 x ULN). According to protocol, treatment was interrupted for > Grade 3 or neutropenia or thrombocytopenia in chronic phase patients. Guidelines for accelerated and blast patients were as noted in the text. 
Hematology parameters 
• Neutropenia 16 47 23 35 26 8 
• Thrombocytopenia 27 33 31 12 17 <1 
• Anemia 40 11 33 6 5 <1 
Biochemistry parameters 
• Elevated creatinine 1.2 0 1.3 0 0.2 0 
• Elevated bilirubin 3.5 0 1.7 0 0.6 0 
• Elevated alkaline phosphatase 4.6 0 5.1 0.4 0.2 0 
• Elevated SGOT (AST) 1.9 0 2.1 0 1.7 0 
• Elevated SGPT (ALT) 2.3 0.4 3.0 0 1.7 0 
Myeloid blast crisisAccelerated phaseChronic phase, interferon failure
n = 260n = 235n = 532
(%)(%)(%)
Grade 3Grade 4Grade 3Grade 4Grade 3Grade 4
CTC grades: neutropenia (grade 3 ≥ 0.5 – 1.0 x 109/L, grade 4 < 0.5 x 109/L), thrombocytopenia (grade 3 ≥ 10 – 50 x 109/L, grade 4 < 10 x 109/L), anemia (hemoglobin ≥ 65 – 80 g/L, grade 4 < 65 g/L), elevated creatinine (grade 3 > 3-6 x upper limit normal range (ULN), grade 4 > 6 x ULN), elevated bilirubin (grade 3 > 3-10 x ULN, grade 4 > 10 x ULN), elevated alkaline phosphatase (grade 3 > 5-20 x ULN, grade 4 > 20 x ULN), elevated SGOT or SGPT (grade 3 > 5-20 x ULN, grade 4 > 20 x ULN). According to protocol, treatment was interrupted for > Grade 3 or neutropenia or thrombocytopenia in chronic phase patients. Guidelines for accelerated and blast patients were as noted in the text. 
Hematology parameters 
• Neutropenia 16 47 23 35 26 8 
• Thrombocytopenia 27 33 31 12 17 <1 
• Anemia 40 11 33 6 5 <1 
Biochemistry parameters 
• Elevated creatinine 1.2 0 1.3 0 0.2 0 
• Elevated bilirubin 3.5 0 1.7 0 0.6 0 
• Elevated alkaline phosphatase 4.6 0 5.1 0.4 0.2 0 
• Elevated SGOT (AST) 1.9 0 2.1 0 1.7 0 
• Elevated SGPT (ALT) 2.3 0.4 3.0 0 1.7 0 
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