Neurocognitive function and anatomical lesion location in children with HbSS: Data from the Cooperative Study of Sickle Cell Disease (CSSCD).
| • Overt stroke: These children had poor performance on most measures. |
| • Silent infarcts in the anterior region: These children performed more poorly (p < 0.05) than children with normal MRI on measures of attention (freedom from distractibility), executive function, and short-term memory. |
| • Silent infarcts in the left hemisphere: These children performed more poorly (p < 0.04) than children with normal magnetic resonance imaging (MRI) on verbal and language function (verbal IQ) and reading achievement (broad reading, letter-word identification, and passage comprehension). |
| • Diffuse silent infarcts: These children showed a trend toward decreased scores for spatial relations and tactile form perception with the dominant hand. |
| • Overt stroke: These children had poor performance on most measures. |
| • Silent infarcts in the anterior region: These children performed more poorly (p < 0.05) than children with normal MRI on measures of attention (freedom from distractibility), executive function, and short-term memory. |
| • Silent infarcts in the left hemisphere: These children performed more poorly (p < 0.04) than children with normal magnetic resonance imaging (MRI) on verbal and language function (verbal IQ) and reading achievement (broad reading, letter-word identification, and passage comprehension). |
| • Diffuse silent infarcts: These children showed a trend toward decreased scores for spatial relations and tactile form perception with the dominant hand. |