Major recommendations for vaccinations for family, close contacts, and health-care workers (HCWs) of hematopoietic stem cell (HSCT) recipients.
| Vaccine . | Recommendations for use . | Rating . |
|---|---|---|
| Hepatitis A | Routine vaccination is recommended for persons at increased risk for hepatitis A or its adverse consequences (e.g., persons with chronic liver disease or persons traveling to hepatitis A-endemic countries) and for children aged ≈ 24 months living in areas with consistently elevated hepatitis A incidence. | BII |
| Influenza | Household contacts – Vaccination is strongly recommended during each influenza season (i.e., October-May) beginning in the season before the transplant and continuing to ≈ 24 months after HSCT. All household contacts of immunocompromised HSCT recipients should be vaccinated annually as long as these conditions persist. | AI |
| HCWs and home caregivers – Annual vaccination is strongly recommended during each influenza seasons | AI | |
| Polio | Vaccination is not routinely recommended for adults but should be administered when polio vaccination is indicated according to published Advisory Committee on Immunization Practices guidelines; when polio vaccine is administered, inactivated polio vaccine should be used. | AI |
| Measles-mumps-rubella | Vaccination is recommended for all persons who are aged ≈12 months and who are not pregnant or immunocompromised. | AI |
| Haemophilus influenzae | Vaccination of pediatric household contacts is recommended to prevent Hib exposure to HSCT patients | AII |
| Rotavirus | Contraindicated because intussusception has been reported among infants during the first 1-2 weeks after rotavirus vaccination with substantially increased frequency. | EII |
| Varicella | Vaccination should be administered to all susceptible HCWs, household contacts, and family members who are aged ≈12 months and who are not pregnant or immunocompromised. When varicella vaccination is administered to persons aged ≈13 years, 2 doses are required, administered 4-8 weeks apart. | AIII |
| Vaccine . | Recommendations for use . | Rating . |
|---|---|---|
| Hepatitis A | Routine vaccination is recommended for persons at increased risk for hepatitis A or its adverse consequences (e.g., persons with chronic liver disease or persons traveling to hepatitis A-endemic countries) and for children aged ≈ 24 months living in areas with consistently elevated hepatitis A incidence. | BII |
| Influenza | Household contacts – Vaccination is strongly recommended during each influenza season (i.e., October-May) beginning in the season before the transplant and continuing to ≈ 24 months after HSCT. All household contacts of immunocompromised HSCT recipients should be vaccinated annually as long as these conditions persist. | AI |
| HCWs and home caregivers – Annual vaccination is strongly recommended during each influenza seasons | AI | |
| Polio | Vaccination is not routinely recommended for adults but should be administered when polio vaccination is indicated according to published Advisory Committee on Immunization Practices guidelines; when polio vaccine is administered, inactivated polio vaccine should be used. | AI |
| Measles-mumps-rubella | Vaccination is recommended for all persons who are aged ≈12 months and who are not pregnant or immunocompromised. | AI |
| Haemophilus influenzae | Vaccination of pediatric household contacts is recommended to prevent Hib exposure to HSCT patients | AII |
| Rotavirus | Contraindicated because intussusception has been reported among infants during the first 1-2 weeks after rotavirus vaccination with substantially increased frequency. | EII |
| Varicella | Vaccination should be administered to all susceptible HCWs, household contacts, and family members who are aged ≈12 months and who are not pregnant or immunocompromised. When varicella vaccination is administered to persons aged ≈13 years, 2 doses are required, administered 4-8 weeks apart. | AIII |