Evidence-based rating system used in the Hematopoietic Stem Cell Transplantation (HSCT) Guidelines.
| Strength of the recommendation . | |
|---|---|
| Category . | Definition . |
| A | Both strong evidence for efficacy and substantial clinical benefit support recommendation for use. Should always be offered. |
| B | Moderate evidence for efficacy—or strong evidence for efficacy, but only limited clinical benefit—supports recommendation for use. Should generally be offered. |
| C | Evidence for efficacy is insufficient to support a recommendation for or against use, or evidence for efficacy might not outweigh adverse consequences, (e.g., drug toxicity, drug interactions), or cost of the chemoprophylaxis or alternative approaches. Optional. |
| D | Moderate evidence for lack of efficacy or for adverse outcome supports a recommendation against use. Should generally not be offered. |
| E | Good evidence for lack of efficacy or for adverse outcome supports arecommendation against use. Should never be offered. |
| Strength of the recommendation . | |
|---|---|
| Category . | Definition . |
| A | Both strong evidence for efficacy and substantial clinical benefit support recommendation for use. Should always be offered. |
| B | Moderate evidence for efficacy—or strong evidence for efficacy, but only limited clinical benefit—supports recommendation for use. Should generally be offered. |
| C | Evidence for efficacy is insufficient to support a recommendation for or against use, or evidence for efficacy might not outweigh adverse consequences, (e.g., drug toxicity, drug interactions), or cost of the chemoprophylaxis or alternative approaches. Optional. |
| D | Moderate evidence for lack of efficacy or for adverse outcome supports a recommendation against use. Should generally not be offered. |
| E | Good evidence for lack of efficacy or for adverse outcome supports arecommendation against use. Should never be offered. |
| Quality of evidence supporting the recommendation . | |
|---|---|
| Category . | Definition . |
| I | Evidence from at least one properly randomized, controlled trial. |
| II | Evidence from at least one well-designed clinical trial without randomization, from cohort or case-controlled analytic studies (preferably from more than one center), or from multiple time-series or dramatic results from uncontrolled experiments. |
| III | Evidence from opinions of respected authorities based on clinical experience, descriptive |
| Quality of evidence supporting the recommendation . | |
|---|---|
| Category . | Definition . |
| I | Evidence from at least one properly randomized, controlled trial. |
| II | Evidence from at least one well-designed clinical trial without randomization, from cohort or case-controlled analytic studies (preferably from more than one center), or from multiple time-series or dramatic results from uncontrolled experiments. |
| III | Evidence from opinions of respected authorities based on clinical experience, descriptive |