Table 7.

Effects of flavopiridol on CLL cells.

Induction of apoptosis 
Independent of prior fludarabine 
Activation of caspase 3 
Cell cycle arrest 
Decreased expression of p53 protein 
Cytotoxicity independent of p53 status 
Down-regulation of Mcl-1 
Induction of apoptosis 
Independent of prior fludarabine 
Activation of caspase 3 
Cell cycle arrest 
Decreased expression of p53 protein 
Cytotoxicity independent of p53 status 
Down-regulation of Mcl-1 
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