Genetic abnormalities in lymphoid neoplasms associated with diagnostically useful protein expression.
| Translocation . | Protein Expression . | Distribution . | Utility . |
|---|---|---|---|
| t(14;18) | Bcl2 | Germinal centers − | Reactive vs neoplastic follicles |
| Follicular lymphoma + | |||
| t(11;14) | Cyclin D1 | Mantle cell lymphoma (all) | Mantle cell lymphoma vs other lymphomas or reactive process |
| Hairy cell leukemia (some) | |||
| Plasma cell myeloma (some) | |||
| t(2;5) | ALK (anaplastic lymphoma kinase) | Anaplastic large-cell lymphoma (most) | ALCL vs other lymphomas; prognosis of ALCL |
| t(1;14) or t(11;18) | Bcl10 | MALT lymphomas unresponsive to Helicobacter pylori eradication | Prognosis/response prediction of MALT lymphomas |
| Translocation . | Protein Expression . | Distribution . | Utility . |
|---|---|---|---|
| t(14;18) | Bcl2 | Germinal centers − | Reactive vs neoplastic follicles |
| Follicular lymphoma + | |||
| t(11;14) | Cyclin D1 | Mantle cell lymphoma (all) | Mantle cell lymphoma vs other lymphomas or reactive process |
| Hairy cell leukemia (some) | |||
| Plasma cell myeloma (some) | |||
| t(2;5) | ALK (anaplastic lymphoma kinase) | Anaplastic large-cell lymphoma (most) | ALCL vs other lymphomas; prognosis of ALCL |
| t(1;14) or t(11;18) | Bcl10 | MALT lymphomas unresponsive to Helicobacter pylori eradication | Prognosis/response prediction of MALT lymphomas |