Chromosomal translocations of non-Hodgkin's lymphoma (NHL).
| NHL histologic type . | Translocation . | % of cases affected . | Proto-oncogene involved . | Mechanism of proto-oncogene activation . | Proto-oncogene function . |
|---|---|---|---|---|---|
| *in the adult population; 85% in childhood. | |||||
| Lymphoplasmacytic lymphoma | t(9;14)(p13;q32) | 50% | PAX-5 | Transcriptional deregulation | Transcription factor regulating B-cell proliferation and differentiation |
| Follicular lymphoma | t(14;18)(q32;q21) t(2;18)(p11;q21) t(18;22)(q21;q11) | 90% | BCL-2 | Transcriptional deregulation | Negative regulator of apoptosis |
| Mantle cell lymphoma | t(11;14)(q13;q32) | 70% | BCL-1/ cyclin D1 | Transcriptional deregulation | Cell cycle regulator |
| MALT lymphoma | t(11;18)(q21;q21) t(1;14)(p22;q32) | 50% rare | API2/MLT BCL-10 | Fusion protein Trancriptional deregulation | API2 has antiapoptotic activity Anti-apoptosis (?) |
| Diffuse large B-cell lymphoma | der(3)(q27) | 35% | BCL-6 | Transcriptional deregulation | Transcriptional repressor required for GC formation |
| Burkitt lymphoma | t(8;14)(q24;q32) t(2;8)(p11;q24) t(8;22)(q24;q11) | 80% 15% 5% | c-MYC | Transcriptional deregulation | Transcription factor regulating cell proliferation and growth |
| Anaplastic large T-cell lymphoma | t(2;5)(p23;q35) | 60%* | NPM/ALK | Fusion protein | ALK is a tyrosine kinase |
| NHL histologic type . | Translocation . | % of cases affected . | Proto-oncogene involved . | Mechanism of proto-oncogene activation . | Proto-oncogene function . |
|---|---|---|---|---|---|
| *in the adult population; 85% in childhood. | |||||
| Lymphoplasmacytic lymphoma | t(9;14)(p13;q32) | 50% | PAX-5 | Transcriptional deregulation | Transcription factor regulating B-cell proliferation and differentiation |
| Follicular lymphoma | t(14;18)(q32;q21) t(2;18)(p11;q21) t(18;22)(q21;q11) | 90% | BCL-2 | Transcriptional deregulation | Negative regulator of apoptosis |
| Mantle cell lymphoma | t(11;14)(q13;q32) | 70% | BCL-1/ cyclin D1 | Transcriptional deregulation | Cell cycle regulator |
| MALT lymphoma | t(11;18)(q21;q21) t(1;14)(p22;q32) | 50% rare | API2/MLT BCL-10 | Fusion protein Trancriptional deregulation | API2 has antiapoptotic activity Anti-apoptosis (?) |
| Diffuse large B-cell lymphoma | der(3)(q27) | 35% | BCL-6 | Transcriptional deregulation | Transcriptional repressor required for GC formation |
| Burkitt lymphoma | t(8;14)(q24;q32) t(2;8)(p11;q24) t(8;22)(q24;q11) | 80% 15% 5% | c-MYC | Transcriptional deregulation | Transcription factor regulating cell proliferation and growth |
| Anaplastic large T-cell lymphoma | t(2;5)(p23;q35) | 60%* | NPM/ALK | Fusion protein | ALK is a tyrosine kinase |