Series of peripheral T/NK cell lymphoma.
| Site . | No. Pts . | PTCL NOS (%) . | ALCL (%) . | AILD (%) . | Angiocentric (%) . | Rare subtypes (%) . | Comments . |
|---|---|---|---|---|---|---|---|
| Abbreviations: PTCL, peripheral T cell lymphoma; NOS, not otherwise specified; ALCL, anaplastic large cell lymphoma; AILD, angioimmunoblastic type PTCL; OS, overall survival; DLBCL, diffuse large B cell lymphoma; DFS, disease free survival; IPI, International Prognostic Index; PFS, progression free survival; ATLL, adult T cell leukemia/lymphoma | |||||||
| Spain32 | 174 | 95 (55) | 30 (17) | 22 (13) | 4 (8) | 13 (7) | ALCL had the best survival (65 mo median); the others were in 20-25 mo range with the in testinal as the predominant rare subtype at only 4 mos. |
| France8 | 288 | 160 (55) | 60 (21) | 68 (24) | - | - | The 5 yr OS for T-ALCL was 64% compared to 53% for DLBCL and 35% for other PTCL. |
| Italy33 | 167 | 78 (47) | 62 (37) | 19 (11) | 2 (1) | 6 (4) | ALCL had a better DFS (66% vs 38%, p=0.0001) than the remaining PTCL. |
| United States34,35 | 78 | 53 (68) | 8 (10) | 7 (9) | 9 (12) | 1 (1) | IPI correlated with 5 yr OS: 76% low, 32% low- intermediate, 28% high-intermediate, 9% high risk. |
| 92 | 28 (30) | 40 (43) | 13 (14) | - | 11 (12) | OS was 49% and PFS was 22% at 5 yr. ALCL had best prognosis (58% OS, 40% PFS) compared to other subtypes. | |
| Korea36 | 125 | 53 (42) | 5 (4) | 5 (4) | 59 (47) | 3 (2) | Angiocentric were primarily nasal/nasopharyngeal origin. PTCL, NOS, had a worse survival compared to DLBCL. |
| Japan 37 | |||||||
| Kyushu | 265 | 83 (27) | 22 (6) | 38 (10) | 28 (8) | 3 (1) | ATLL accounted for 181 (52%) in Kyushu and 47 (15%) in other areas, for a combined 238 cases in Japan. |
| Other | 315 | 130 (41) | 27 (9) | 39 (12) | 55 (17) | 17 (5) | |
| Site . | No. Pts . | PTCL NOS (%) . | ALCL (%) . | AILD (%) . | Angiocentric (%) . | Rare subtypes (%) . | Comments . |
|---|---|---|---|---|---|---|---|
| Abbreviations: PTCL, peripheral T cell lymphoma; NOS, not otherwise specified; ALCL, anaplastic large cell lymphoma; AILD, angioimmunoblastic type PTCL; OS, overall survival; DLBCL, diffuse large B cell lymphoma; DFS, disease free survival; IPI, International Prognostic Index; PFS, progression free survival; ATLL, adult T cell leukemia/lymphoma | |||||||
| Spain32 | 174 | 95 (55) | 30 (17) | 22 (13) | 4 (8) | 13 (7) | ALCL had the best survival (65 mo median); the others were in 20-25 mo range with the in testinal as the predominant rare subtype at only 4 mos. |
| France8 | 288 | 160 (55) | 60 (21) | 68 (24) | - | - | The 5 yr OS for T-ALCL was 64% compared to 53% for DLBCL and 35% for other PTCL. |
| Italy33 | 167 | 78 (47) | 62 (37) | 19 (11) | 2 (1) | 6 (4) | ALCL had a better DFS (66% vs 38%, p=0.0001) than the remaining PTCL. |
| United States34,35 | 78 | 53 (68) | 8 (10) | 7 (9) | 9 (12) | 1 (1) | IPI correlated with 5 yr OS: 76% low, 32% low- intermediate, 28% high-intermediate, 9% high risk. |
| 92 | 28 (30) | 40 (43) | 13 (14) | - | 11 (12) | OS was 49% and PFS was 22% at 5 yr. ALCL had best prognosis (58% OS, 40% PFS) compared to other subtypes. | |
| Korea36 | 125 | 53 (42) | 5 (4) | 5 (4) | 59 (47) | 3 (2) | Angiocentric were primarily nasal/nasopharyngeal origin. PTCL, NOS, had a worse survival compared to DLBCL. |
| Japan 37 | |||||||
| Kyushu | 265 | 83 (27) | 22 (6) | 38 (10) | 28 (8) | 3 (1) | ATLL accounted for 181 (52%) in Kyushu and 47 (15%) in other areas, for a combined 238 cases in Japan. |
| Other | 315 | 130 (41) | 27 (9) | 39 (12) | 55 (17) | 17 (5) | |