Table 9.

Characteristic features of CD56+ neoplasms with blast morphology.

FeatureBlastic NK-cell LymphomaAggressive NK-cell Leukemia*Myeloid/NK-cell Precursor Leukemia
++ = >50%; + = 25%-50%; +/- = 5%-25%; - = <5% 
* Tumor cells vary from mature-appearing large granular lymphocytes (LGLs) to cells with a more blastic appearance 
** note: 13%-41% of AML overall are CD56+ 
the number of blasts may be small and involvement patchy compared to other leukemias 
Marrow involvement ++ ++ ++** 
Skin disease ++ < 10% 
Lymph node involvement ++ ++ 
Hepatosplenomegaly ∼15% < 10% 
Epstein-Barr virus +/- 
Cytoplasmic granules +/- 
FeatureBlastic NK-cell LymphomaAggressive NK-cell Leukemia*Myeloid/NK-cell Precursor Leukemia
++ = >50%; + = 25%-50%; +/- = 5%-25%; - = <5% 
* Tumor cells vary from mature-appearing large granular lymphocytes (LGLs) to cells with a more blastic appearance 
** note: 13%-41% of AML overall are CD56+ 
the number of blasts may be small and involvement patchy compared to other leukemias 
Marrow involvement ++ ++ ++** 
Skin disease ++ < 10% 
Lymph node involvement ++ ++ 
Hepatosplenomegaly ∼15% < 10% 
Epstein-Barr virus +/- 
Cytoplasmic granules +/- 
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