Characteristic features of CD56+ neoplasms with blast morphology.
Feature . | Blastic NK-cell Lymphoma . | Aggressive NK-cell Leukemia* . | Myeloid/NK-cell Precursor Leukemia . |
---|---|---|---|
++ = >50%; + = 25%-50%; +/- = 5%-25%; - = <5% | |||
* Tumor cells vary from mature-appearing large granular lymphocytes (LGLs) to cells with a more blastic appearance | |||
** note: 13%-41% of AML overall are CD56+ | |||
† the number of blasts may be small and involvement patchy compared to other leukemias | |||
Marrow involvement | ++ | ++† | ++** |
Skin disease | ++ | - | < 10% |
Lymph node involvement | + | ++ | ++ |
Hepatosplenomegaly | ∼15% | + | < 10% |
Epstein-Barr virus | - | +/- | - |
Cytoplasmic granules | +/- | + | - |
Feature . | Blastic NK-cell Lymphoma . | Aggressive NK-cell Leukemia* . | Myeloid/NK-cell Precursor Leukemia . |
---|---|---|---|
++ = >50%; + = 25%-50%; +/- = 5%-25%; - = <5% | |||
* Tumor cells vary from mature-appearing large granular lymphocytes (LGLs) to cells with a more blastic appearance | |||
** note: 13%-41% of AML overall are CD56+ | |||
† the number of blasts may be small and involvement patchy compared to other leukemias | |||
Marrow involvement | ++ | ++† | ++** |
Skin disease | ++ | - | < 10% |
Lymph node involvement | + | ++ | ++ |
Hepatosplenomegaly | ∼15% | + | < 10% |
Epstein-Barr virus | - | +/- | - |
Cytoplasmic granules | +/- | + | - |