General comparison of immature and mature NK-cell neoplasms.
| Immature . | Mature . |
|---|---|
| *True NK LGL leukemia is not associated with EBV Abbreviations: TIA, EBV, Epstein-Barr virus; LGL, large granular lymphocyte | |
| Blastic morphology | Small, medium or large lymphocytes |
| Azurophilic granules inconspicuous or absent | Azurophilic granules present |
| TIA-1 usually negative | TIA-1+ |
| Lacks killer activity in vitro | Has killer activity in vitro |
| EBV- | EBV+* |
| Immature . | Mature . |
|---|---|
| *True NK LGL leukemia is not associated with EBV Abbreviations: TIA, EBV, Epstein-Barr virus; LGL, large granular lymphocyte | |
| Blastic morphology | Small, medium or large lymphocytes |
| Azurophilic granules inconspicuous or absent | Azurophilic granules present |
| TIA-1 usually negative | TIA-1+ |
| Lacks killer activity in vitro | Has killer activity in vitro |
| EBV- | EBV+* |