ALKgene dysregulation and the classification of anaplastic large cell lymphoma (ALCL).
Abbreviations: SCV, small cell variant; EMA, epithelial membrane antigen; LyP, lymphomatoid papulosis; MF, mycosis fungoides; HD, Hodgkin's disease; HIV, human immunodeficiency virus |
ALK-positive Group |
Distinct clinicopathologic entity: |
•young patients |
•systemic disease |
•variable histology (ALCL → SCV) |
•T or null cell, EMA+ |
ALK-negative Group |
Heterogeneous group of lymphomas: |
•primary cutaneous |
•Hodgkin's related |
•Secondary ALCL in patients with LyP, MF, HD |
•CD30+ large B-cell lymphomas |
•ALCL in HIV+ patients |
Abbreviations: SCV, small cell variant; EMA, epithelial membrane antigen; LyP, lymphomatoid papulosis; MF, mycosis fungoides; HD, Hodgkin's disease; HIV, human immunodeficiency virus |
ALK-positive Group |
Distinct clinicopathologic entity: |
•young patients |
•systemic disease |
•variable histology (ALCL → SCV) |
•T or null cell, EMA+ |
ALK-negative Group |
Heterogeneous group of lymphomas: |
•primary cutaneous |
•Hodgkin's related |
•Secondary ALCL in patients with LyP, MF, HD |
•CD30+ large B-cell lymphomas |
•ALCL in HIV+ patients |