Response to salvage therapy in patients retreated after failing or relapsing from fludarabine regimens (data from 27).
| . | Fludarabine Retreatment . | Other Treatment . | ||||||
|---|---|---|---|---|---|---|---|---|
| Initial Response . | CR . | PR . | Total Pts . | % . | CR . | PR . | Total Pts . | % . |
| Overall response | 13 | 28 | 63 | 67 | 4 | 3 | 28 | 25 |
| Complete remission | 10 | 8 | 25 | 72 | 1 | 0 | 4 | 25 |
| Nodular partial remission | 3 | 13 | 23 | 64 | 1 | 1 | 7 | 28 |
| Partial remission | 0 | 7 | 11 | 70 | 0 | 0 | 5 | — |
| Fail 0 | 0 | 4 | — | 2 | 2 | 12 | 33 | |
| . | Fludarabine Retreatment . | Other Treatment . | ||||||
|---|---|---|---|---|---|---|---|---|
| Initial Response . | CR . | PR . | Total Pts . | % . | CR . | PR . | Total Pts . | % . |
| Overall response | 13 | 28 | 63 | 67 | 4 | 3 | 28 | 25 |
| Complete remission | 10 | 8 | 25 | 72 | 1 | 0 | 4 | 25 |
| Nodular partial remission | 3 | 13 | 23 | 64 | 1 | 1 | 7 | 28 |
| Partial remission | 0 | 7 | 11 | 70 | 0 | 0 | 5 | — |
| Fail 0 | 0 | 4 | — | 2 | 2 | 12 | 33 | |
| Regimen . | CR . | PR . | Total Pts . | % . |
|---|---|---|---|---|
| Abbreviations: CR, complete response; PR, partial response | ||||
| Fludarabine (3 or 5 days) | 8 | 18 | 35 | 74 |
| Fludarabine + Mitoxantrone | 0 | 3 | 9 | 33 |
| Fludarabine + Doxorubicin + Prednisone (FLAP) | 1 | 0 | 4 | 25 |
| Fludarabine + Cytosine Arabinoside + Cis-platinum | 0 | 0 | 2 | 0 |
| Fludarabine + Cyclophosphamide | 4 | 7 | 13 | 85 |
| 2-CDA | 0 | 1 | 2 | 50 |
| Cyclophosphamide + Doxorubicin + Vincristine + Prednisone (CHOP) | 2 | 2 | 7 | 57 |
| Chlorambucil | 0 | 2 | — | |
| Allogeneic bone marrow transplant | 2 | 0 | 4 | 50 |
| VP-16 | 0 | 3 | — | |
| Taxol | 0 | 2 | — | |
| Adriamycin + Cytosine Arabinoside + Cis-platinum (ASHAP) | 0 | 1 | — | |
| Topetecan | 0 | 7 | — | |
| Regimen . | CR . | PR . | Total Pts . | % . |
|---|---|---|---|---|
| Abbreviations: CR, complete response; PR, partial response | ||||
| Fludarabine (3 or 5 days) | 8 | 18 | 35 | 74 |
| Fludarabine + Mitoxantrone | 0 | 3 | 9 | 33 |
| Fludarabine + Doxorubicin + Prednisone (FLAP) | 1 | 0 | 4 | 25 |
| Fludarabine + Cytosine Arabinoside + Cis-platinum | 0 | 0 | 2 | 0 |
| Fludarabine + Cyclophosphamide | 4 | 7 | 13 | 85 |
| 2-CDA | 0 | 1 | 2 | 50 |
| Cyclophosphamide + Doxorubicin + Vincristine + Prednisone (CHOP) | 2 | 2 | 7 | 57 |
| Chlorambucil | 0 | 2 | — | |
| Allogeneic bone marrow transplant | 2 | 0 | 4 | 50 |
| VP-16 | 0 | 3 | — | |
| Taxol | 0 | 2 | — | |
| Adriamycin + Cytosine Arabinoside + Cis-platinum (ASHAP) | 0 | 1 | — | |
| Topetecan | 0 | 7 | — | |