Table 1. Pathology of moribund Socs1 Iox... | American Society of Hematology

Table 1.

Pathology of moribund Socs1^Iox/−LysM-cre and Socs1^Iox/−Alb-cre/LysM-cre mice

	*Socs1^Iox/−non-Tg*	*Socs1^Iox/−LysM-cre*	*Socs1^Iox/−Alb-cre/LysM-cre*
No. mice	9	16	10
Spleen, % mice with lesion
Enlargement	0	63	100
Reticuloendothelial cell hyperplasia	0	75	100
Lymphoid follicles	100	81	90
Germinal centers	100	25	20
Excess erythroid cells	66	93	100
Lymph node, % mice with lesion
Reticuloendothelial cell hyperplasia	0	63	70
Thymus, % mice with lesion
Atrophy of the cortex	0	100	100
BM, % mice with lesion
Granulocytic > mononuclear cells	11	87	90
Liver, % mice with lesion
Minor infiltration	0	50	10
Major infiltration	0	50	90
Hepatocyte damage	0	25	70
Pancreas, % mice with lesion
Infiltration	0	50	50
Lung, % mice with lesion
Macrophage/lymphocyte cuffing	0	75	80
Macrophage/lymphocyte foci	0	50	70
Pneumonia	0	50	40
Skeletal muscle, % mice with lesion
Infiltration	0	50	30
Gut, % mice with lesion
Infiltration	0	60	40
Skin, % mice with lesion
Epithelia hyperplasia	11	19	20
Body weight, g^*	21.6 ± 1.7	20.1 ± 1.6	20.4 ± 0.9
Spleen weight, mg^*	95 ± 33	849 ± 405‡	860 ± 247†

	*Socs1^Iox/−non-Tg*	*Socs1^Iox/−LysM-cre*	*Socs1^Iox/−Alb-cre/LysM-cre*
No. mice	9	16	10
Spleen, % mice with lesion
Enlargement	0	63	100
Reticuloendothelial cell hyperplasia	0	75	100
Lymphoid follicles	100	81	90
Germinal centers	100	25	20
Excess erythroid cells	66	93	100
Lymph node, % mice with lesion
Reticuloendothelial cell hyperplasia	0	63	70
Thymus, % mice with lesion
Atrophy of the cortex	0	100	100
BM, % mice with lesion
Granulocytic > mononuclear cells	11	87	90
Liver, % mice with lesion
Minor infiltration	0	50	10
Major infiltration	0	50	90
Hepatocyte damage	0	25	70
Pancreas, % mice with lesion
Infiltration	0	50	50
Lung, % mice with lesion
Macrophage/lymphocyte cuffing	0	75	80
Macrophage/lymphocyte foci	0	50	70
Pneumonia	0	50	40
Skeletal muscle, % mice with lesion
Infiltration	0	50	30
Gut, % mice with lesion
Infiltration	0	60	40
Skin, % mice with lesion
Epithelia hyperplasia	11	19	20
Body weight, g^*	21.6 ± 1.7	20.1 ± 1.6	20.4 ± 0.9
Spleen weight, mg^*	95 ± 33	849 ± 405‡	860 ± 247†

^*For body and spleen weights, 6 nontransgenic, 6 LysM-cre, and 2 Alb-cre/LysM-cre mice were analyzed. The means ± SD are shown. Statistical significance (Mann-Whitney test): †P < .05; ‡P < .001.

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