Table 6.

Direct recognition and lysis of leukemia cells by NIK-1: experiment 3



% cytotoxicity, at cold-hot target cell ratio
Hot target cells and cold target cells
0
5:1
10:1
20:1
C2F8 cells     
WT1 peptide-loaded autologous LCL   31.3   22.5   14.3   9.6  
Peptide-unloaded autologous LCL   31.3   30.5   29.7   28.1  
Freshly isolated leukemia cells from donor no. 1 (AML M1)     
WT1 peptide-loaded autologous LCL   42.1   26.4   15.2   8.8  
Peptide-unloaded autologous LCL
 
42.1
 
41.3
 
39.3
 
40.2
 


% cytotoxicity, at cold-hot target cell ratio
Hot target cells and cold target cells
0
5:1
10:1
20:1
C2F8 cells     
WT1 peptide-loaded autologous LCL   31.3   22.5   14.3   9.6  
Peptide-unloaded autologous LCL   31.3   30.5   29.7   28.1  
Freshly isolated leukemia cells from donor no. 1 (AML M1)     
WT1 peptide-loaded autologous LCL   42.1   26.4   15.2   8.8  
Peptide-unloaded autologous LCL
 
42.1
 
41.3
 
39.3
 
40.2
 

Cytotoxicity of NIK-1 against leukemia cells in the presence or absence of WT1 peptide-loaded autologous LCL or peptide-unloaded autologous LCL at an effector-hot target cell ratio of 10:1.

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