Direct recognition and lysis of leukemia cells by NIK-1: experiment 3
. | % cytotoxicity, at cold-hot target cell ratio . | . | . | . | |||
---|---|---|---|---|---|---|---|
Hot target cells and cold target cells . | 0 . | 5:1 . | 10:1 . | 20:1 . | |||
C2F8 cells | |||||||
WT1 peptide-loaded autologous LCL | 31.3 | 22.5 | 14.3 | 9.6 | |||
Peptide-unloaded autologous LCL | 31.3 | 30.5 | 29.7 | 28.1 | |||
Freshly isolated leukemia cells from donor no. 1 (AML M1) | |||||||
WT1 peptide-loaded autologous LCL | 42.1 | 26.4 | 15.2 | 8.8 | |||
Peptide-unloaded autologous LCL | 42.1 | 41.3 | 39.3 | 40.2 |
. | % cytotoxicity, at cold-hot target cell ratio . | . | . | . | |||
---|---|---|---|---|---|---|---|
Hot target cells and cold target cells . | 0 . | 5:1 . | 10:1 . | 20:1 . | |||
C2F8 cells | |||||||
WT1 peptide-loaded autologous LCL | 31.3 | 22.5 | 14.3 | 9.6 | |||
Peptide-unloaded autologous LCL | 31.3 | 30.5 | 29.7 | 28.1 | |||
Freshly isolated leukemia cells from donor no. 1 (AML M1) | |||||||
WT1 peptide-loaded autologous LCL | 42.1 | 26.4 | 15.2 | 8.8 | |||
Peptide-unloaded autologous LCL | 42.1 | 41.3 | 39.3 | 40.2 |
Cytotoxicity of NIK-1 against leukemia cells in the presence or absence of WT1 peptide-loaded autologous LCL or peptide-unloaded autologous LCL at an effector-hot target cell ratio of 10:1.