WT1-specific and HLA-DP5-restricted cytotoxicity by NIK-1: experiment 3
WT1 peptide loaded . | % cytotoxicity, at 10:1 E/T ratio . |
|---|---|
| None | 3.5 |
| KLSHLQMHSRKHTGEKPYQC | 73.5 |
| KLSHLQMHSRKHTGEKPYQ | 68.5 |
| KLSHLQMHSRKHTGEKPY | 73.1 |
| KLSHLQMHSRKHTGEKP | 58.6 |
| KLSHLQMHSRKHTGEK | 70.2 |
| KLSHLQMHSRKHTGE | 71.5 |
| KLSHLQMHSRKHTG | 71.2 |
| KLSHLQMHSRKHT | 73.1 |
| KLSHLQMHSRKH | 72.7 |
| KLSHLQMHSRK | 32.5 |
| KLSHLQMHSR | 7.3 |
| KLSHLQMHS | 7.5 |
| LSHLQMHSRKHTGEKPYQC | 63.9 |
| SHLQMHSRKHTGEKPYQC | 32.4 |
| HLQMHSRKHTGEKPYQC | 6.6 |
| LQMHSRKHTGEKPYQC | 6.9 |
| QMHSRKHTGEKPYQC | 4.9 |
| MHSRKHTGEKPYQC | 6.4 |
| HSRKHTGEKPYQC | 5.9 |
| SRKHTGEKPYQC | 7.2 |
| RKHTGEKPYQC | 3.5 |
| KHTGEKPYQC | 7.8 |
| HTGEKPYQC | 7.7 |
| LSHLQMHSRKH | 72.1 |
WT1 peptide loaded . | % cytotoxicity, at 10:1 E/T ratio . |
|---|---|
| None | 3.5 |
| KLSHLQMHSRKHTGEKPYQC | 73.5 |
| KLSHLQMHSRKHTGEKPYQ | 68.5 |
| KLSHLQMHSRKHTGEKPY | 73.1 |
| KLSHLQMHSRKHTGEKP | 58.6 |
| KLSHLQMHSRKHTGEK | 70.2 |
| KLSHLQMHSRKHTGE | 71.5 |
| KLSHLQMHSRKHTG | 71.2 |
| KLSHLQMHSRKHT | 73.1 |
| KLSHLQMHSRKH | 72.7 |
| KLSHLQMHSRK | 32.5 |
| KLSHLQMHSR | 7.3 |
| KLSHLQMHS | 7.5 |
| LSHLQMHSRKHTGEKPYQC | 63.9 |
| SHLQMHSRKHTGEKPYQC | 32.4 |
| HLQMHSRKHTGEKPYQC | 6.6 |
| LQMHSRKHTGEKPYQC | 6.9 |
| QMHSRKHTGEKPYQC | 4.9 |
| MHSRKHTGEKPYQC | 6.4 |
| HSRKHTGEKPYQC | 5.9 |
| SRKHTGEKPYQC | 7.2 |
| RKHTGEKPYQC | 3.5 |
| KHTGEKPYQC | 7.8 |
| HTGEKPYQC | 7.7 |
| LSHLQMHSRKH | 72.1 |
Cytotoxicity of NIK-1 against autologous LCL loaded and unloaded with various WT1 peptides. E/T ratio indicates effector-target ratio.