Major recurring genetic events in DLBCL
Genetic defect . | Frequency . | Location . | Mechanism of deregulation . |
|---|---|---|---|
| BCL6 | 35%-40%12 | 3q27 | t(3;...) and SHM |
| BCL2 | t(14;18) 13%,79 amplification 24%21 | 18q21 | t(14;18) and gene amplification |
| cMYC | 15%22 | 8q24 | t(8;...) and SHM |
| FAS(CD95) | 20%24 | 10q24 | Death domain mutations, ?SHM |
| SHM | 45%31 | Physiologic: Ig(v), FAS, BCL6 Aberrant: BCL6, PIM1, cMYC, PAX5, RhoH/TTF, ?FAS | SHM |
| p53 | 16%11 | 17p | Mutation, deletion |
Genetic defect . | Frequency . | Location . | Mechanism of deregulation . |
|---|---|---|---|
| BCL6 | 35%-40%12 | 3q27 | t(3;...) and SHM |
| BCL2 | t(14;18) 13%,79 amplification 24%21 | 18q21 | t(14;18) and gene amplification |
| cMYC | 15%22 | 8q24 | t(8;...) and SHM |
| FAS(CD95) | 20%24 | 10q24 | Death domain mutations, ?SHM |
| SHM | 45%31 | Physiologic: Ig(v), FAS, BCL6 Aberrant: BCL6, PIM1, cMYC, PAX5, RhoH/TTF, ?FAS | SHM |
| p53 | 16%11 | 17p | Mutation, deletion |