Table 6. Larger studies on... | American Society of Hematology

Table 6.

Larger studies on erythropoietin (Epo) alone or Epo in combination with G-CSF.

Author	Year	Treatment	No. Pts.	Inclusion Criteria	Erythroid Response	Favorable Variables/Comments
Hellstrom-Lindberg⁴⁰ meta-analysis	1995	Epo	205	Various, all studies since 1995	16%^* (8% RARS)	S-Epo < 200 U/L RA/RAEB, no transfusions
Rose⁴¹ phase II	1995	Epo	116	Hb < 80 g/L, S-Epo < 500 U/L	28%^** (18% red. transf)	S-Epo < 100 U/L, RA
Italian Study Group⁴² phase III	1998	Epo / placebo	87	Hb < 90 g/L Blasts < 10%	37% vs 11%^** (p = 0.007)	Response significant in RA and in non-transfused pts
Negrin⁴⁴ phase II	1996	Epo + G-CSF	55	Hb < 100 g/L	48%^**, duration median 10 mo.	S-Epo
Hellstrom-Lindberg⁴⁵ phase II	1998	Epo + G-CSF	71	Hb < 100 g/L	38%^*, duration 24 months	S-Epo, transfusion need
Remacha⁴⁷ phase II	1999	Epo + G-CSF	32	Hb < 100 g/L S-Epo < 250 U/L	50%^**	Predictive model (Figure 5)
Mantovani⁴⁹	2000	Epo + G-CSF	33	Blasts < 20%	61%^* (12 weeks) 80% (36 weeks)	50% response after 2 years
Abbreviations: S-Epo, serum Epo level; G-CSF, granulocyte colony-stimulating factor

Author	Year	Treatment	No. Pts.	Inclusion Criteria	Erythroid Response	Favorable Variables/Comments
Hellstrom-Lindberg⁴⁰ meta-analysis	1995	Epo	205	Various, all studies since 1995	16%^* (8% RARS)	S-Epo < 200 U/L RA/RAEB, no transfusions
Rose⁴¹ phase II	1995	Epo	116	Hb < 80 g/L, S-Epo < 500 U/L	28%^** (18% red. transf)	S-Epo < 100 U/L, RA
Italian Study Group⁴² phase III	1998	Epo / placebo	87	Hb < 90 g/L Blasts < 10%	37% vs 11%^** (p = 0.007)	Response significant in RA and in non-transfused pts
Negrin⁴⁴ phase II	1996	Epo + G-CSF	55	Hb < 100 g/L	48%^**, duration median 10 mo.	S-Epo
Hellstrom-Lindberg⁴⁵ phase II	1998	Epo + G-CSF	71	Hb < 100 g/L	38%^*, duration 24 months	S-Epo, transfusion need
Remacha⁴⁷ phase II	1999	Epo + G-CSF	32	Hb < 100 g/L S-Epo < 250 U/L	50%^**	Predictive model (Figure 5)
Mantovani⁴⁹	2000	Epo + G-CSF	33	Blasts < 20%	61%^* (12 weeks) 80% (36 weeks)	50% response after 2 years
Abbreviations: S-Epo, serum Epo level; G-CSF, granulocyte colony-stimulating factor

The definition of response required a total stop in transfusion need in transfusion-dependent patients.

The definition of response required a 50% reduction in transfusion need in transfusion-dependent patients.