Large or new allogeneic stem cell transplantation studies in myelodysplastic syndromes.
| Author (Year)Ref. No. pts (period) . | Age M (range) . | Donor Related/VUD . | Outcome . | Comments . | |
|---|---|---|---|---|---|
. | . | . | DFS . | Relapse . | . |
| Appelbaum (1998)3 251 (1981-96) | 38 (1-66) | 59% / 28% | 40% at 6y (60% < 20y, 20% > 50y) | 18% | Age, IPSS highly predictive for DFS |
| Nevill (1998)4 60 (1986-96) | 40 (15-55) | 38/22 | 29% at 7y | 42% | 6% DFS in poor cytogenetic risk group |
| de Witte (2000)5 1378 (1997) | not given | 885/198 | 36% at 3 y36% 25% (VUD) | (all) | Relapse rate in patients with >5% blasts 42-43%, in MDS-AML 49% |
| Deeg (2000)6 50 (1989-98)* | 59 (55-66) | 36/6 | 42% at 3y | 19% | DFS in RA, 53%. In high cytogenetic risk group 21% |
| Abbreviations: DFS, disease-free survival; RA, refractory anemia; VUD, volunteer unrelated donor; IPSS, International Scoring System for Evaluating Prognosis | |||||
| Author (Year)Ref. No. pts (period) . | Age M (range) . | Donor Related/VUD . | Outcome . | Comments . | |
|---|---|---|---|---|---|
. | . | . | DFS . | Relapse . | . |
| Appelbaum (1998)3 251 (1981-96) | 38 (1-66) | 59% / 28% | 40% at 6y (60% < 20y, 20% > 50y) | 18% | Age, IPSS highly predictive for DFS |
| Nevill (1998)4 60 (1986-96) | 40 (15-55) | 38/22 | 29% at 7y | 42% | 6% DFS in poor cytogenetic risk group |
| de Witte (2000)5 1378 (1997) | not given | 885/198 | 36% at 3 y36% 25% (VUD) | (all) | Relapse rate in patients with >5% blasts 42-43%, in MDS-AML 49% |
| Deeg (2000)6 50 (1989-98)* | 59 (55-66) | 36/6 | 42% at 3y | 19% | DFS in RA, 53%. In high cytogenetic risk group 21% |
| Abbreviations: DFS, disease-free survival; RA, refractory anemia; VUD, volunteer unrelated donor; IPSS, International Scoring System for Evaluating Prognosis | |||||
Two patients transplanted 1978 and 1983