Table 2. Evidence for an immune-mediated... | American Society of Hematology

Table 2.

Evidence for an immune-mediated suppression of the marrow in myelodysplastic syndrome (MDS).

T cells inhibit MDS CFU-E
CD8+ cells inhibit CFU-GM
Immunosuppressive agents improve cytopenia in MDS and eliminate autosuppressive T cells
T cells are activated in MDS
T cells show a skewed T cell receptor V-β repertoire
HLA DR15 over representation in MDS and aplastic anemia

Abbreviations: CFU-E, colony-forming units-erythroid; CFU-GM, colony-forming units-granulocyte/macrophage