Table 1.

Platelet membrane glycoprotein alleles.*

Glycoprotein
Alleles
Gene Frequency
HPA-Determinants
Integrin Subunit α2  Allele 2: Glu505, Thr799**  0.53   5a, 12aw  
  Allele 1: Glu505, Thr799  0.39   5a, 12aw  
  Allele 3: Lys505, Thr799  0.076  5b, 12aw  
  Allele 4: Glu505, Met799  <0.01   5a, 12bw 
GPIb α   Thr145, VNTR C isoform   0.82 (0.539)   2a  
  Thr145, VNTR D isoform   0.11 (0.296)   2a  
 Met145, VNTR B isoform   0.07 (0.01)  2b 
 Met145, VNTR C isoform   <0.01 (<0.01)  2b 
 Met145, VNTR A isoform   <0.01 (0.155)  2b 
GPIb β   Gly15  0.99   11aw  
 Glu15  <0.01  11bw 
Integrin Subunit αIIb  Val837, Ile843  0.61   3a, 9a  
  Val837, Ser843  0.36  3b, 9a  
 Met837, Ser843  0.03  3b, 9b 
Integrin Subunit b3  Leu33, Leu40, Arg62, Arg143, Pro407, Arg489, Arg636  0.85   1a, 10a, 4a, 7a, 6a, 8a  
 Pro33, Leu40, Arg62, Arg143, Pro407, Arg489, Arg636  0.15  1b, 10a, 4a, 7a, 6a, 8a  
 Pro33, Arg40, Arg62, Arg143, Pro407, Arg489, Arg636  0.005  1b, 10a, 4a, 7a, 6a, 8a  
  Leu33, Leu40, Gln62, Arg143, Pro407, Arg489, Arg636  <0.001   1a, 10b, 4a, 7a, 6a, 8a  
  Leu33, Leu40, Arg62, Gln143, Pro407, Arg489, Arg636  <0.01   1a, 10a, 4b, 7a, 6a, 8a  
  Leu33, Leu40, Arg62, Arg143, Ala407, Arg489, Arg636  <0.001   1a, 10a, 4a, 7b, 6a, 8a  
  Leu33, Leu40, Arg62, Arg143, Pro407, Gln489, Arg636  <0.001   1a, 10a, 4a, 7a, 6b, 8a  
  Leu33, Leu40, Arg62, Arg143, Pro407, Arg489, Cys636  <0.001   1a, 10a, 4a, 7a, 6a, 8b 
Gene frequencies are for Caucasian populations or Japanese populations (in parentheses).  
Glycoprotein
Alleles
Gene Frequency
HPA-Determinants
Integrin Subunit α2  Allele 2: Glu505, Thr799**  0.53   5a, 12aw  
  Allele 1: Glu505, Thr799  0.39   5a, 12aw  
  Allele 3: Lys505, Thr799  0.076  5b, 12aw  
  Allele 4: Glu505, Met799  <0.01   5a, 12bw 
GPIb α   Thr145, VNTR C isoform   0.82 (0.539)   2a  
  Thr145, VNTR D isoform   0.11 (0.296)   2a  
 Met145, VNTR B isoform   0.07 (0.01)  2b 
 Met145, VNTR C isoform   <0.01 (<0.01)  2b 
 Met145, VNTR A isoform   <0.01 (0.155)  2b 
GPIb β   Gly15  0.99   11aw  
 Glu15  <0.01  11bw 
Integrin Subunit αIIb  Val837, Ile843  0.61   3a, 9a  
  Val837, Ser843  0.36  3b, 9a  
 Met837, Ser843  0.03  3b, 9b 
Integrin Subunit b3  Leu33, Leu40, Arg62, Arg143, Pro407, Arg489, Arg636  0.85   1a, 10a, 4a, 7a, 6a, 8a  
 Pro33, Leu40, Arg62, Arg143, Pro407, Arg489, Arg636  0.15  1b, 10a, 4a, 7a, 6a, 8a  
 Pro33, Arg40, Arg62, Arg143, Pro407, Arg489, Arg636  0.005  1b, 10a, 4a, 7a, 6a, 8a  
  Leu33, Leu40, Gln62, Arg143, Pro407, Arg489, Arg636  <0.001   1a, 10b, 4a, 7a, 6a, 8a  
  Leu33, Leu40, Arg62, Gln143, Pro407, Arg489, Arg636  <0.01   1a, 10a, 4b, 7a, 6a, 8a  
  Leu33, Leu40, Arg62, Arg143, Ala407, Arg489, Arg636  <0.001   1a, 10a, 4a, 7b, 6a, 8a  
  Leu33, Leu40, Arg62, Arg143, Pro407, Gln489, Arg636  <0.001   1a, 10a, 4a, 7a, 6b, 8a  
  Leu33, Leu40, Arg62, Arg143, Pro407, Arg489, Cys636  <0.001   1a, 10a, 4a, 7a, 6a, 8b 
Gene frequencies are for Caucasian populations or Japanese populations (in parentheses).  
*

Adapted from Newman PJ et al.38,39 

**

Alleles 1 and 2 of integrin α2 are defined by several linked dimorphisms that are silent (see 25 ).

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