Primary structure of CMV vaccine peptides.
| Lipid Molecule(s) . | Adaptor Sequence . | TH Type . | TH Epitope Sequence . | Linker Sequence . | CMV CTL Epitope Sequence pp65495-503 . | Carboxyl Terminus . |
|---|---|---|---|---|---|---|
| A. 2 Palmitic Acids | -K-S-S- | PADRE | -A-K-X*-V-A-A-W-T-L-K-A-A-A- | NONE | -N-L-V-P-M-V-A-T-V- | OH |
| B. 2 Palmitic Acids | -K-S-S- | Tetanus | -Q-Y-I-K-A-N-S-K-F-I-G-I-T-E- | -A-A-A- | -N-L-V-P-M-V-A-T-V- | OH |
| The sequences of two vaccines, peptides A and B, are shown. These peptides are proposed for testing in the setting of HCT to prevent CMV disease by active vaccination of donors. The derivation and use of the PADRE TH peptide can be found in ref. # 120, and the tetanus peptide is discussed in ref. # 132 and # 131. | ||||||
| Lipid Molecule(s) . | Adaptor Sequence . | TH Type . | TH Epitope Sequence . | Linker Sequence . | CMV CTL Epitope Sequence pp65495-503 . | Carboxyl Terminus . |
|---|---|---|---|---|---|---|
| A. 2 Palmitic Acids | -K-S-S- | PADRE | -A-K-X*-V-A-A-W-T-L-K-A-A-A- | NONE | -N-L-V-P-M-V-A-T-V- | OH |
| B. 2 Palmitic Acids | -K-S-S- | Tetanus | -Q-Y-I-K-A-N-S-K-F-I-G-I-T-E- | -A-A-A- | -N-L-V-P-M-V-A-T-V- | OH |
| The sequences of two vaccines, peptides A and B, are shown. These peptides are proposed for testing in the setting of HCT to prevent CMV disease by active vaccination of donors. The derivation and use of the PADRE TH peptide can be found in ref. # 120, and the tetanus peptide is discussed in ref. # 132 and # 131. | ||||||