Distribution of HLA alleles for known CMV CTL epitopes.
| . | . | . | . | HLA Antigen Frequency (%) . | |||
|---|---|---|---|---|---|---|---|
| HLA A or B Allele . | CMV Protein . | CTL HLA Restriction Characterized . | Sequence of CTL Epitope Defined . | CA . | BL . | CH . | HS . |
| HLA A*0101 | pp65 | Yes | Yes | 28.6 | 10.1 | 9.2 | 10.1 |
| HLA A*0201 | pp65 | Yes | Yes | 45.8 | 30.3 | 54.9 | 43.0 |
| HLA A*0301 | pp150 | Yes | Yes | 20.6 | 16.3 | 7.1 | 14.8 |
| HLA A*1101/2 | pp65 | Yes | Yes | 9.9 | 3.8 | 33.1 | 7.3 |
| HLA A*2401/2 | pp65 | Yes | Yes | 16.8 | 8.8 | 32.9 | 26.7 |
| HLA A*6801 | pp65 | Yes | Yes | 8.8 | 20.8 | 0.8 | 20.8 |
| HLA A*6801 | pp150 | Yes | Yes | 8.8 | 20.8 | 0.8 | 20.8 |
| HLA B*0702 | pp65 | Yes | Yes | 17.7 | 15.5 | 6.9 | 11.8 |
| HLA B*3502 | pp65 | Yes | Yes | 3.6 | 3.5 | 2.3 | 6.6 |
| HLA B*3801/2 | pp65 | Yes | Yes | 7.6 | 0.2 | 3.4 | 3.6 |
| HLA B*62 | pp150 | Yes | Yes | 10.3 | 2.6 | 14.3 | 3.0 |
| CTL epitopes were defined as minimal cytotoxic epitopes (MCE) as described in the text. Frequencies of HLA alleles in ethnic populations defined as CA (Caucasian), BL (black), CH (Chinese), and HS (Hispanic) are from the 11th International Histocompatibility Workshop.144 Two CTL epitopes in CMVpp65 restricted by HLA B*0702 and HLA A*6801 have been defined. | |||||||
| . | . | . | . | HLA Antigen Frequency (%) . | |||
|---|---|---|---|---|---|---|---|
| HLA A or B Allele . | CMV Protein . | CTL HLA Restriction Characterized . | Sequence of CTL Epitope Defined . | CA . | BL . | CH . | HS . |
| HLA A*0101 | pp65 | Yes | Yes | 28.6 | 10.1 | 9.2 | 10.1 |
| HLA A*0201 | pp65 | Yes | Yes | 45.8 | 30.3 | 54.9 | 43.0 |
| HLA A*0301 | pp150 | Yes | Yes | 20.6 | 16.3 | 7.1 | 14.8 |
| HLA A*1101/2 | pp65 | Yes | Yes | 9.9 | 3.8 | 33.1 | 7.3 |
| HLA A*2401/2 | pp65 | Yes | Yes | 16.8 | 8.8 | 32.9 | 26.7 |
| HLA A*6801 | pp65 | Yes | Yes | 8.8 | 20.8 | 0.8 | 20.8 |
| HLA A*6801 | pp150 | Yes | Yes | 8.8 | 20.8 | 0.8 | 20.8 |
| HLA B*0702 | pp65 | Yes | Yes | 17.7 | 15.5 | 6.9 | 11.8 |
| HLA B*3502 | pp65 | Yes | Yes | 3.6 | 3.5 | 2.3 | 6.6 |
| HLA B*3801/2 | pp65 | Yes | Yes | 7.6 | 0.2 | 3.4 | 3.6 |
| HLA B*62 | pp150 | Yes | Yes | 10.3 | 2.6 | 14.3 | 3.0 |
| CTL epitopes were defined as minimal cytotoxic epitopes (MCE) as described in the text. Frequencies of HLA alleles in ethnic populations defined as CA (Caucasian), BL (black), CH (Chinese), and HS (Hispanic) are from the 11th International Histocompatibility Workshop.144 Two CTL epitopes in CMVpp65 restricted by HLA B*0702 and HLA A*6801 have been defined. | |||||||