Sensitivity and specificity for leukemia classification using SVM in 13 subgroups
. | Patients and controls (N = 937) . | Sensitivity, % . | . | Specificity, % . | . | ||
|---|---|---|---|---|---|---|---|
| Leukemia classification . | . | Median . | 95% CI . | Median . | 95% CI . | ||
| c-ALL/pre-B-ALL | 82 | 92.9 | 82.1-100 | 99.7 | 98.6-100 | ||
| Pro-B-ALL with t(11q23) | 26 | 100 | 77.8-100 | 100 | 100-100 | ||
| Mature B-ALL with t(8;14) | 12 | 75 | 25-100 | 100 | 99.4-100 | ||
| T-ALL | 32 | 90 | 70-100 | 100 | 99.7-100 | ||
| AML with t(15;17) | 42 | 100 | 100-100 | 100 | 100-100 | ||
| AML with t(8;21) | 38 | 100 | 83.3-100 | 100 | 99.7-100 | ||
| AML with inv(16) | 49 | 100 | 87.5-100 | 100 | 100-100 | ||
| AML with t(11q23) | 47 | 81.3 | 62.5-100 | 99.7 | 99-100 | ||
| AML with complex karyotype | 75 | 86 | 72-96 | 99.7 | 98.6-100 | ||
| AML normal/other | 369 | 96.8 | 94.3-99.2 | 93.7 | 90.2-96.6 | ||
| CLL | 45 | 100 | 93.3-100 | 100 | 100-100 | ||
| CML | 75 | 96 | 84-100 | 99.7 | 98.6-100 | ||
| Nonleukemia | 45 | 90 | 66.3-100 | 99.7 | 98.3-100 | ||
. | Patients and controls (N = 937) . | Sensitivity, % . | . | Specificity, % . | . | ||
|---|---|---|---|---|---|---|---|
| Leukemia classification . | . | Median . | 95% CI . | Median . | 95% CI . | ||
| c-ALL/pre-B-ALL | 82 | 92.9 | 82.1-100 | 99.7 | 98.6-100 | ||
| Pro-B-ALL with t(11q23) | 26 | 100 | 77.8-100 | 100 | 100-100 | ||
| Mature B-ALL with t(8;14) | 12 | 75 | 25-100 | 100 | 99.4-100 | ||
| T-ALL | 32 | 90 | 70-100 | 100 | 99.7-100 | ||
| AML with t(15;17) | 42 | 100 | 100-100 | 100 | 100-100 | ||
| AML with t(8;21) | 38 | 100 | 83.3-100 | 100 | 99.7-100 | ||
| AML with inv(16) | 49 | 100 | 87.5-100 | 100 | 100-100 | ||
| AML with t(11q23) | 47 | 81.3 | 62.5-100 | 99.7 | 99-100 | ||
| AML with complex karyotype | 75 | 86 | 72-96 | 99.7 | 98.6-100 | ||
| AML normal/other | 369 | 96.8 | 94.3-99.2 | 93.7 | 90.2-96.6 | ||
| CLL | 45 | 100 | 93.3-100 | 100 | 100-100 | ||
| CML | 75 | 96 | 84-100 | 99.7 | 98.6-100 | ||
| Nonleukemia | 45 | 90 | 66.3-100 | 99.7 | 98.3-100 | ||
Overall median accuracy was 93.8% (95% CI, 91.4%-95.8%).