PNH: clinical heterogeneity and proposed terminology (from 40 ).
| Predominant Clinical Features . | Blood Findings . | Size of PNH Clone . | Designation . |
|---|---|---|---|
| Hemolysis ± thrombosis | Anemia; little or no other cytopenia | Large | Florid PNH |
| Hemolysis ± thrombosis | Anemia; mild to moderate other cytopenia(s) | Large | PNH, hypoplastic |
| Purpura and/or infection | Moderate to severe pancytopenia | Large | AA/PNH |
| Purpura and/or infection | Severe pancytopenia | Small | AA with PNH clone |
| Thrombosis | Normal or moderate cytopenia(s) | Small | Mini-PNH |
| Predominant Clinical Features . | Blood Findings . | Size of PNH Clone . | Designation . |
|---|---|---|---|
| Hemolysis ± thrombosis | Anemia; little or no other cytopenia | Large | Florid PNH |
| Hemolysis ± thrombosis | Anemia; mild to moderate other cytopenia(s) | Large | PNH, hypoplastic |
| Purpura and/or infection | Moderate to severe pancytopenia | Large | AA/PNH |
| Purpura and/or infection | Severe pancytopenia | Small | AA with PNH clone |
| Thrombosis | Normal or moderate cytopenia(s) | Small | Mini-PNH |