Predictors of outcome post donor lymphocyte infusion (DLI) in chronic myelogenous leukemia (CML) relapse following allogeneic stem cell transplantation (SCT). Results compare presence vs absence of the variable in question.
| Study (Reference)/Variables . | % Response . | % GVHD . | % Aplasia . | |||
|---|---|---|---|---|---|---|
| Variable | P | A | P | A | P | A |
| Kolb(69) | ||||||
| CP at DLI | 80 | 2 | ||||
| No GVHD with BMT | 84 | 64 | ||||
| IFN treatment | 73 | 51 | 52 | 24 | ||
| Hematologic relapse | 68 | 45 | 49 | 12 | ||
| Collins(70) | ||||||
| CP at DLI | 81 | 44 | ||||
| No GVHD with BMT | 64 | 86 | 72 | 91 | ||
| Caucasian | 64 | 85 | 72 | 94 | ||
| IFN treatment | 74 | 81 | ||||
| Shimoni(71) | ||||||
| CP at DLI | 87 | 9 | ||||
| Time to relapse < 12 months | 23 | 85 | ||||
| Sibling donor | 40 | 100 | ||||
| Dazzi(74) | ||||||
| Bulk DLI | 67 | 91 | 44 | 10 | ||
| Abbreviations: P, presence; A, absence; CP, chronic phase; DLI, donor lymphocyte infusion; GVHD, graft-versus-host disease; BMT, bone marrow transplantation; IFN, interferon | ||||||
| Study (Reference)/Variables . | % Response . | % GVHD . | % Aplasia . | |||
|---|---|---|---|---|---|---|
| Variable | P | A | P | A | P | A |
| Kolb(69) | ||||||
| CP at DLI | 80 | 2 | ||||
| No GVHD with BMT | 84 | 64 | ||||
| IFN treatment | 73 | 51 | 52 | 24 | ||
| Hematologic relapse | 68 | 45 | 49 | 12 | ||
| Collins(70) | ||||||
| CP at DLI | 81 | 44 | ||||
| No GVHD with BMT | 64 | 86 | 72 | 91 | ||
| Caucasian | 64 | 85 | 72 | 94 | ||
| IFN treatment | 74 | 81 | ||||
| Shimoni(71) | ||||||
| CP at DLI | 87 | 9 | ||||
| Time to relapse < 12 months | 23 | 85 | ||||
| Sibling donor | 40 | 100 | ||||
| Dazzi(74) | ||||||
| Bulk DLI | 67 | 91 | 44 | 10 | ||
| Abbreviations: P, presence; A, absence; CP, chronic phase; DLI, donor lymphocyte infusion; GVHD, graft-versus-host disease; BMT, bone marrow transplantation; IFN, interferon | ||||||