Summary of X-inactivation studies in polycythemia vera.
| Gene(s) . | Method . | F . | L . | T . | WBC . | G . | PI . | Ret . | RBC . | NK . |
|---|---|---|---|---|---|---|---|---|---|---|
| G6PD | Protein | 0/2 | 0/2 | 2/2 | 2/2 | 2/2 | ||||
| PGK, HPRT | DNA | 5/6 | ||||||||
| PGK | DNA | 1/1 | ||||||||
| PGK | DNA | 0/3 | 16/17 | 3/3 | ||||||
| PGK | DNA | 0/1 | 2/3 | |||||||
| PGK, HPRT | DNA | 1/8 | 8/8 | |||||||
| AR | DNA | 4/25 | 21/25 | |||||||
| AR | DNA | 2/10 | 0/3 | 7/11 | ||||||
| AR | DNA | 14/22 | ||||||||
| P55, G6PD | RNA | 0/3 | 3/3 | 3/3 | 3/3 | 0/3 | ||||
| (Adapted from Hinschelwood S et al, 1997)3 | ||||||||||
| Key: For each cell type, numbers represent the number of patients with a skewed X-inactivation ratio over the total number of patients studied. Abbreviations: F, skin or marrow fibroblasts; L, lymphocytes; T, T lymphocytes; WBC, white blood cells; G, granulocytes; PI, platelets; Ret, reticulocytes; RBC, red blood cells; NK, natural killer cells; G6PD, glucose-6-phosphate dehydrogenase; PGK, phosphoglycerate kinase; HPRT, hypoxanthine phosphoryl ribosyl transferase; AR, androgen receptor | ||||||||||
| Gene(s) . | Method . | F . | L . | T . | WBC . | G . | PI . | Ret . | RBC . | NK . |
|---|---|---|---|---|---|---|---|---|---|---|
| G6PD | Protein | 0/2 | 0/2 | 2/2 | 2/2 | 2/2 | ||||
| PGK, HPRT | DNA | 5/6 | ||||||||
| PGK | DNA | 1/1 | ||||||||
| PGK | DNA | 0/3 | 16/17 | 3/3 | ||||||
| PGK | DNA | 0/1 | 2/3 | |||||||
| PGK, HPRT | DNA | 1/8 | 8/8 | |||||||
| AR | DNA | 4/25 | 21/25 | |||||||
| AR | DNA | 2/10 | 0/3 | 7/11 | ||||||
| AR | DNA | 14/22 | ||||||||
| P55, G6PD | RNA | 0/3 | 3/3 | 3/3 | 3/3 | 0/3 | ||||
| (Adapted from Hinschelwood S et al, 1997)3 | ||||||||||
| Key: For each cell type, numbers represent the number of patients with a skewed X-inactivation ratio over the total number of patients studied. Abbreviations: F, skin or marrow fibroblasts; L, lymphocytes; T, T lymphocytes; WBC, white blood cells; G, granulocytes; PI, platelets; Ret, reticulocytes; RBC, red blood cells; NK, natural killer cells; G6PD, glucose-6-phosphate dehydrogenase; PGK, phosphoglycerate kinase; HPRT, hypoxanthine phosphoryl ribosyl transferase; AR, androgen receptor | ||||||||||