The phenotype of neoplastic cells in classical and nodular lymphocyte-predominant Hodgkin's disease.
. | Classical HL RS cells . | Atypical Lymphocytic and Histiocytic Cells (LPHD) . |
|---|---|---|
| CD20 | Occasionally positive | Usually positive |
| Other B cell antigens | Usually negative | Usually positive |
| J chain | Negative | Positive |
| CD30 | Positive | Negative |
| CD15 | Usually positive | Negative |
| EBV genome | Often positive | Infrequently positive |
| Abbreviations: HL, Hodgkin's lymphoma; RS, Reed-Sternberg cells; LPHD, lymphocyte-predominant Hodgkin's lymphoma; EBV, Epstein-Barr virus | ||
. | Classical HL RS cells . | Atypical Lymphocytic and Histiocytic Cells (LPHD) . |
|---|---|---|
| CD20 | Occasionally positive | Usually positive |
| Other B cell antigens | Usually negative | Usually positive |
| J chain | Negative | Positive |
| CD30 | Positive | Negative |
| CD15 | Usually positive | Negative |
| EBV genome | Often positive | Infrequently positive |
| Abbreviations: HL, Hodgkin's lymphoma; RS, Reed-Sternberg cells; LPHD, lymphocyte-predominant Hodgkin's lymphoma; EBV, Epstein-Barr virus | ||