Table 3. Summary of results using... | American Society of Hematology

Table 3.

Summary of results using chemotherapy to treat PTLD in solid organ transplant patients.⁸¹

Series	Regimen	No. Patients	CR Rate	Relapse Rate	Rejection Rate	Toxic Death^*	1-Year DFS
Swinnen, et al²¹	ProMACE-CytaBOM	11	55%	0%	0%	27%	45%
Morrison, et al¹²	CHOP +/- Bleo, COMLA, M-BACOD, VACOP-B, Ifos/VP-16/Dex	9	11%	0%	0%	NR	11%
Garrett, et al²²	CHOP	4	100%	0%	0%	25%	75%
Hayashi, et al²³	CY, Adria, VCR, MTX, AraC + IT, ABVD-MOPP^** (2 HD)	10	80%	10%	0%	0%	70%
Gross, et al	CY/Pred^***	35	83%	14%	11%	6%	81%
Abbreviations: Promace-CytoBOM, prednisone, vincristine (VCR), doxorubicin (Adria), methotrexate (MTx), cytosine arabinoside (Ara-C), bleomycin (Bleo), cyclophosphamide (Cy), etoposide (Vp 16); CHOP, Cy, Adria, VCR, prednisone; COMLA, Cy, VCR, MTx, Leukcovorin, Ara-C; M-BACOD, Mtx, Bleo, Cy, VCR, dexamethasone (Dex); VACOP-B, Vp6, Adria, Cy, VCR, Bleo; Ifos, ifosfamide; IT, intrathecal; CR, complete remission; DFS, disease-free survival

Series	Regimen	No. Patients	CR Rate	Relapse Rate	Rejection Rate	Toxic Death^*	1-Year DFS
Swinnen, et al²¹	ProMACE-CytaBOM	11	55%	0%	0%	27%	45%
Morrison, et al¹²	CHOP +/- Bleo, COMLA, M-BACOD, VACOP-B, Ifos/VP-16/Dex	9	11%	0%	0%	NR	11%
Garrett, et al²²	CHOP	4	100%	0%	0%	25%	75%
Hayashi, et al²³	CY, Adria, VCR, MTX, AraC + IT, ABVD-MOPP^** (2 HD)	10	80%	10%	0%	0%	70%
Gross, et al	CY/Pred^***	35	83%	14%	11%	6%	81%
Abbreviations: Promace-CytoBOM, prednisone, vincristine (VCR), doxorubicin (Adria), methotrexate (MTx), cytosine arabinoside (Ara-C), bleomycin (Bleo), cyclophosphamide (Cy), etoposide (Vp 16); CHOP, Cy, Adria, VCR, prednisone; COMLA, Cy, VCR, MTx, Leukcovorin, Ara-C; M-BACOD, Mtx, Bleo, Cy, VCR, dexamethasone (Dex); VACOP-B, Vp6, Adria, Cy, VCR, Bleo; Ifos, ifosfamide; IT, intrathecal; CR, complete remission; DFS, disease-free survival

Toxic deaths include death not due to progressive disease while on therapy

For two patients with Hodgkin's disease

CY (600mg/m²) + Prednisone × 5 days every 3 weeks