Table 1. Main clinical and biologic... | American Society of Hematology

Table 1.

Main clinical and biologic features of the patients with childhood AML analyzed

	Total			NPN1 wt			NPM1 mut	NPM1 mutated within subgroup, %
	n	% total	n	% total	n	% total		NPM1 mutated within subgroup, %
Total	107	100	100	93.5	7	6.5	0
Sex
Male	55	51.4	51	51.0	4	57.1	7.3
Female	52	48.6	49	49.0	3	42.9	5.8
Age
Median
Younger than 5 y	37	34.6	36	36.0	1	14.3	2.7
5-10 y	25	23.4	24	24.0	1	14.3	4.0
Older than 10 y	45	42.1	40	40.0	5	71.4	11.1
FAB^*
M0	6	6.3	6	6.7	0	0	0
M1	21	21.9	20	22.5	1	14.3	4.8
M2	19	19.8	17	19.1	2	28.6	10.5
M4	13	13.5	10	11.2	3	42.9	23.1
M4eo	8	8.3	8	9.0	0	0	0
M5	18	18.8	18	20.2	0	0	0
M6	3	3.1	2	2.2	1	14.3	33.3
M7	8	8.3	8	9.0	0	0	0
Karyotype^*
Normal	26	27.1	19	21.3	7	100.0	26.9
t(8;21)	17	17.7	17	19.1	0	0	0
inv(16)/t(16;16)	8	8.3	8	9.0	0	0	0
t(11q23)	18	18.8	18	20.2	0	0	0
Trysomy 8	4	4.2	4	4.5	0	0	0
−	6	6.3	6	6.7	0	0	0
Other/Complex	17	17.7	17	19.1	0	0	0
				1680-		5450-
WBC, × 10⁶/L	35 500	1680-475 000†	35 650	475 000†	16 000	113 900†	NA

	Total			NPN1 wt			NPM1 mut	NPM1 mutated within subgroup, %
	n	% total	n	% total	n	% total		NPM1 mutated within subgroup, %
Total	107	100	100	93.5	7	6.5	0
Sex
Male	55	51.4	51	51.0	4	57.1	7.3
Female	52	48.6	49	49.0	3	42.9	5.8
Age
Median
Younger than 5 y	37	34.6	36	36.0	1	14.3	2.7
5-10 y	25	23.4	24	24.0	1	14.3	4.0
Older than 10 y	45	42.1	40	40.0	5	71.4	11.1
FAB^*
M0	6	6.3	6	6.7	0	0	0
M1	21	21.9	20	22.5	1	14.3	4.8
M2	19	19.8	17	19.1	2	28.6	10.5
M4	13	13.5	10	11.2	3	42.9	23.1
M4eo	8	8.3	8	9.0	0	0	0
M5	18	18.8	18	20.2	0	0	0
M6	3	3.1	2	2.2	1	14.3	33.3
M7	8	8.3	8	9.0	0	0	0
Karyotype^*
Normal	26	27.1	19	21.3	7	100.0	26.9
t(8;21)	17	17.7	17	19.1	0	0	0
inv(16)/t(16;16)	8	8.3	8	9.0	0	0	0
t(11q23)	18	18.8	18	20.2	0	0	0
Trysomy 8	4	4.2	4	4.5	0	0	0
−	6	6.3	6	6.7	0	0	0
Other/Complex	17	17.7	17	19.1	0	0	0
				1680-		5450-
WBC, × 10⁶/L	35 500	1680-475 000†	35 650	475 000†	16 000	113 900†	NA

NA indicates not applicable.

n = 96 (89.7%) of 107.

Values are ranges, not % total as for the rest of the column.