Intercellular communication signature in TACIhi MMCs and plasmablastic signature in TACIlo MMCs
Genes coding for protein implicated in different functions . | No. genes* . | TACIlo, % . | TACIhi, % . | P† . |
|---|---|---|---|---|
| Intercellular communication signals | 69 | 2.1 | 26.3 | < .001 |
| Cytoskeleton | 20 | 2.1 | 7.2 | .04 |
| Transduction signals | 52 | 11.2 | 17 | .05 |
| Protein synthesis and regulation | 19 | 7.7 | 4.8 | NS |
| Cell cycle | 11 | 10 | 0.8 | < .001 |
| Metabolism | 85 | 22.1 | 26.6 | NS |
| Apoptosis | 10 | 4.2 | 2.8 | NS |
| Nuclear functions | 73 | 40.6 | 15.2 | < .001 |
| Total of classified genes | 339 | 100‡ | 100§ | NS |
Genes coding for protein implicated in different functions . | No. genes* . | TACIlo, % . | TACIhi, % . | P† . |
|---|---|---|---|---|
| Intercellular communication signals | 69 | 2.1 | 26.3 | < .001 |
| Cytoskeleton | 20 | 2.1 | 7.2 | .04 |
| Transduction signals | 52 | 11.2 | 17 | .05 |
| Protein synthesis and regulation | 19 | 7.7 | 4.8 | NS |
| Cell cycle | 11 | 10 | 0.8 | < .001 |
| Metabolism | 85 | 22.1 | 26.6 | NS |
| Apoptosis | 10 | 4.2 | 2.8 | NS |
| Nuclear functions | 73 | 40.6 | 15.2 | < .001 |
| Total of classified genes | 339 | 100‡ | 100§ | NS |
Of the 659 genes differentially expressed between the TACIhi and TACIlo groups, 339 could be assigned to 8 functional categories using gene ontology terms. Data are the percentages of genes of a given category compared with the total number of TACIlo (91 genes) or TACIhi (248 genes) genes.
NS indicates not significant.
n indicates the number of genes out of the 339 in one category
The statistical comparisons of the percentages of genes belonging to one gene ontology category between the TACIlo and TACIhi group genes were performed with the chi-square test
n = 91
n = 248