Table 2.

Response rates and duration in subcategories of patients in the long-term follow-up of 3 studies on treatment with Epo and G-CSF


Group

Total no. patients

No. responding patients

RR, %

CER, %

PER, %

Median response duration, mo (range)*

P
All   123   48   39   22   17   23 (3-116)   —  
Complete responders   27   NA   NA   NA   NA   29 (4-116)   .006  
Partial responders   21   NA   NA   NA   NA   12 (3-93)   —  
FAB        
    RA   28   11   39   18   21   27 (4-62)   .83 
    RARS   40   20   50   38   13   28 (3-116)   —  
    RA + RARS   68   31   46   29   16   28 (3-116)   .04 
    RAEB   55   17   31   13   18   11 (3-93)   —  
IPSS        
    Low/Int-1   88   40   46   27   18   25 (3-116)   .002  
    Int-2/High   26   7   27   12   15   7 (3-23)   —  
Predictive group for response        
    Good   42   25   60   36   24   24 (3-116)   .95§ 
    Intermediate   44   8   18   9   9   23 (4-93)   —  
    Poor
 
16
 
1
 
6
 
0
 
6
 
3
 

 

Group

Total no. patients

No. responding patients

RR, %

CER, %

PER, %

Median response duration, mo (range)*

P
All   123   48   39   22   17   23 (3-116)   —  
Complete responders   27   NA   NA   NA   NA   29 (4-116)   .006  
Partial responders   21   NA   NA   NA   NA   12 (3-93)   —  
FAB        
    RA   28   11   39   18   21   27 (4-62)   .83 
    RARS   40   20   50   38   13   28 (3-116)   —  
    RA + RARS   68   31   46   29   16   28 (3-116)   .04 
    RAEB   55   17   31   13   18   11 (3-93)   —  
IPSS        
    Low/Int-1   88   40   46   27   18   25 (3-116)   .002  
    Int-2/High   26   7   27   12   15   7 (3-23)   —  
Predictive group for response        
    Good   42   25   60   36   24   24 (3-116)   .95§ 
    Intermediate   44   8   18   9   9   23 (4-93)   —  
    Poor
 
16
 
1
 
6
 
0
 
6
 
3
 

 

RR indicates response rate; NA, not applicable.

*

Only for the 41 patients entering the maintenance phase.

P value of RA versus RARS.

P value of RA + RARS versus RAEB.

§

P value of predictive group good versus intermediate.

There is no range because this figure represents one patient.

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