Response rates and duration in subcategories of patients in the long-term follow-up of 3 studies on treatment with Epo and G-CSF
Group . | Total no. patients . | No. responding patients . | RR, % . | CER, % . | PER, % . | Median response duration, mo (range)* . | P . |
|---|---|---|---|---|---|---|---|
| All | 123 | 48 | 39 | 22 | 17 | 23 (3-116) | — |
| Complete responders | 27 | NA | NA | NA | NA | 29 (4-116) | .006 |
| Partial responders | 21 | NA | NA | NA | NA | 12 (3-93) | — |
| FAB | |||||||
| RA | 28 | 11 | 39 | 18 | 21 | 27 (4-62) | .83† |
| RARS | 40 | 20 | 50 | 38 | 13 | 28 (3-116) | — |
| RA + RARS | 68 | 31 | 46 | 29 | 16 | 28 (3-116) | .04‡ |
| RAEB | 55 | 17 | 31 | 13 | 18 | 11 (3-93) | — |
| IPSS | |||||||
| Low/Int-1 | 88 | 40 | 46 | 27 | 18 | 25 (3-116) | .002 |
| Int-2/High | 26 | 7 | 27 | 12 | 15 | 7 (3-23) | — |
| Predictive group for response | |||||||
| Good | 42 | 25 | 60 | 36 | 24 | 24 (3-116) | .95§ |
| Intermediate | 44 | 8 | 18 | 9 | 9 | 23 (4-93) | — |
| Poor | 16 | 1 | 6 | 0 | 6 | 3∥ | — |
Group . | Total no. patients . | No. responding patients . | RR, % . | CER, % . | PER, % . | Median response duration, mo (range)* . | P . |
|---|---|---|---|---|---|---|---|
| All | 123 | 48 | 39 | 22 | 17 | 23 (3-116) | — |
| Complete responders | 27 | NA | NA | NA | NA | 29 (4-116) | .006 |
| Partial responders | 21 | NA | NA | NA | NA | 12 (3-93) | — |
| FAB | |||||||
| RA | 28 | 11 | 39 | 18 | 21 | 27 (4-62) | .83† |
| RARS | 40 | 20 | 50 | 38 | 13 | 28 (3-116) | — |
| RA + RARS | 68 | 31 | 46 | 29 | 16 | 28 (3-116) | .04‡ |
| RAEB | 55 | 17 | 31 | 13 | 18 | 11 (3-93) | — |
| IPSS | |||||||
| Low/Int-1 | 88 | 40 | 46 | 27 | 18 | 25 (3-116) | .002 |
| Int-2/High | 26 | 7 | 27 | 12 | 15 | 7 (3-23) | — |
| Predictive group for response | |||||||
| Good | 42 | 25 | 60 | 36 | 24 | 24 (3-116) | .95§ |
| Intermediate | 44 | 8 | 18 | 9 | 9 | 23 (4-93) | — |
| Poor | 16 | 1 | 6 | 0 | 6 | 3∥ | — |