Gross and histologic findings in singly and doubly transgenic animals
Genotype, gross findings (no./age, mo.) . | Histologic findings (no. mice with feature) . |
|---|---|
| tTA tg (2/4-5) | |
| WNL | WNL* |
| NRASV12 tg (2/4-5) | |
| WNL | WNL |
| tTA;NRASV12 tg (9/4-5) | |
| Splenomegaly, normal color to pale with multiple prominent foci | 20%-100% effaced by well-differentiated mast cell tumor, large clusters of myeloid cell (9) |
| Hepatomegaly, diffuse granular and pale, occasional prominent foci | Multifocal sinusoidal metastases of mast cell tumor, in small islands, widespread (9) |
| Multiple cutaneous lesions, hair loss, and scabbing | Mast cell tumor (9) |
| Femur, pale | Large focal pale areas of well-differentiated mast cells, myeloid cells increased (9) |
| Skeletal muscle, rare foci | Large, well-differentiated mast cell tumor, invasive (9) |
| Kidney, rare foci | Small mast cell clusters in interstitium (2) |
| Lung, rare foci | Single mast cells and small clusters in interstitium (1) |
| Thymus, enlarged | Mast cell tumor (1) |
| Lymph nodes, enlarged | Mast cell tumor (9) |
| Peripheral blood | 2%-80% mast cells (9) |
Genotype, gross findings (no./age, mo.) . | Histologic findings (no. mice with feature) . |
|---|---|
| tTA tg (2/4-5) | |
| WNL | WNL* |
| NRASV12 tg (2/4-5) | |
| WNL | WNL |
| tTA;NRASV12 tg (9/4-5) | |
| Splenomegaly, normal color to pale with multiple prominent foci | 20%-100% effaced by well-differentiated mast cell tumor, large clusters of myeloid cell (9) |
| Hepatomegaly, diffuse granular and pale, occasional prominent foci | Multifocal sinusoidal metastases of mast cell tumor, in small islands, widespread (9) |
| Multiple cutaneous lesions, hair loss, and scabbing | Mast cell tumor (9) |
| Femur, pale | Large focal pale areas of well-differentiated mast cells, myeloid cells increased (9) |
| Skeletal muscle, rare foci | Large, well-differentiated mast cell tumor, invasive (9) |
| Kidney, rare foci | Small mast cell clusters in interstitium (2) |
| Lung, rare foci | Single mast cells and small clusters in interstitium (1) |
| Thymus, enlarged | Mast cell tumor (1) |
| Lymph nodes, enlarged | Mast cell tumor (9) |
| Peripheral blood | 2%-80% mast cells (9) |
WNL indicates within normal limits