IRP2-/- and IRP1+/- IRP2-/- mice have microcytic anemia
. | IRP1+/+ . | IRP1+/+ . | IRP1+/- . |
|---|---|---|---|
. | IRP2+/+ . | IRP2-/- . | IRP2-/- . |
| RBC count, × 106 μL | 9.0 ± 0.3 | 9.0 ± 0.3 | 8.7 ± 0.6 |
| Hemoglobin level, g/dL | 13.2 ± 0.9 | 11.4 ± 0.5 | 10.1 ± 0.8 |
| Hematocrit level, % | 45.2 ± 1.2 | 36.0 ± 1.3 | 32.9 ± 2.2 |
| Mean cell volume, fL | 50.3 ± 0.9 | 40.2 ± 1.2 | 37.9 ± 1.3 |
| Mean corpuscular hemoglobin concentration, g/dL | 29.3 ± 2.3 | 31.5 ± 1.0 | 30.75 ± 1.0 |
. | IRP1+/+ . | IRP1+/+ . | IRP1+/- . |
|---|---|---|---|
. | IRP2+/+ . | IRP2-/- . | IRP2-/- . |
| RBC count, × 106 μL | 9.0 ± 0.3 | 9.0 ± 0.3 | 8.7 ± 0.6 |
| Hemoglobin level, g/dL | 13.2 ± 0.9 | 11.4 ± 0.5 | 10.1 ± 0.8 |
| Hematocrit level, % | 45.2 ± 1.2 | 36.0 ± 1.3 | 32.9 ± 2.2 |
| Mean cell volume, fL | 50.3 ± 0.9 | 40.2 ± 1.2 | 37.9 ± 1.3 |
| Mean corpuscular hemoglobin concentration, g/dL | 29.3 ± 2.3 | 31.5 ± 1.0 | 30.75 ± 1.0 |
Hematocrits of IRP2-/- mice were significantly decreased relative to WT (P < .001) and in IRP1+/- IRP2-/- animals (P < .001). Mean cell volumes were also significantly decreased in IRP2-/- mice relative to WT (P < .001) and in IRP1+/- IRP2-/- animals (P < .001). Data are presented as mean values ± standard deviation.