Representative gene ontology categories enriched in VH3-21+ and non-VH3-21B-CLL
GO category . | O . | E . | R . | P . |
|---|---|---|---|---|
| Biologic process | ||||
| Up-regulated in VH3-21+ B-CLL | ||||
| Cell organization and biogenesis | 19 | 10 | 1.9 | .005 |
| Cell cycle | 23 | 10.77 | 2.14 | <.001 |
| Regulation of cell cycle | 15 | 6.49 | 2.31 | .002 |
| DNA replication and chromosome cycle | 8 | 2.78 | 2.88 | .006 |
| Protein modification | 30 | 17.42 | 1.72 | .002 |
| Protein amino acid dephosphorylation | 6 | 1.68 | 3.57 | .007 |
| Protein amino acid phosphorylation | 19 | 7.70 | 2.47 | <.001 |
| Transmembrane receptor protein tyrosine kinase signaling pathway* | ||||
| Signal complex formation | 2 | 0.12 | 16.67 | .006 |
| Down-regulated In VH3-21+ B-CLL | ||||
| Transport* | ||||
| Intracellular transport | 13 | 6.26 | 2.08 | .01 |
| Molecular function | ||||
| Up-regulated In VH3-21+ B-CLL | ||||
| Transferase activity, transferring phosphorus-containing groups | 25 | 11.7 | 2.14 | <.001 |
| Kinase activity | 24 | 10.39 | 2.31 | <.001 |
| Down-regulated In VH3-21+ B-CLL | ||||
| Protein kinase regulator activity | 4 | 0.76 | 5.26 | .007 |
| Protein kinase inhibitor activity | 3 | 0.38 | 7.89 | .006 |
| Hydrogen ion transport activity | 6 | 1.83 | 3.28 | .01 |
| Cytochrome-c oxidase activity | 3 | 0.34 | 8.82 | .004 |
GO category . | O . | E . | R . | P . |
|---|---|---|---|---|
| Biologic process | ||||
| Up-regulated in VH3-21+ B-CLL | ||||
| Cell organization and biogenesis | 19 | 10 | 1.9 | .005 |
| Cell cycle | 23 | 10.77 | 2.14 | <.001 |
| Regulation of cell cycle | 15 | 6.49 | 2.31 | .002 |
| DNA replication and chromosome cycle | 8 | 2.78 | 2.88 | .006 |
| Protein modification | 30 | 17.42 | 1.72 | .002 |
| Protein amino acid dephosphorylation | 6 | 1.68 | 3.57 | .007 |
| Protein amino acid phosphorylation | 19 | 7.70 | 2.47 | <.001 |
| Transmembrane receptor protein tyrosine kinase signaling pathway* | ||||
| Signal complex formation | 2 | 0.12 | 16.67 | .006 |
| Down-regulated In VH3-21+ B-CLL | ||||
| Transport* | ||||
| Intracellular transport | 13 | 6.26 | 2.08 | .01 |
| Molecular function | ||||
| Up-regulated In VH3-21+ B-CLL | ||||
| Transferase activity, transferring phosphorus-containing groups | 25 | 11.7 | 2.14 | <.001 |
| Kinase activity | 24 | 10.39 | 2.31 | <.001 |
| Down-regulated In VH3-21+ B-CLL | ||||
| Protein kinase regulator activity | 4 | 0.76 | 5.26 | .007 |
| Protein kinase inhibitor activity | 3 | 0.38 | 7.89 | .006 |
| Hydrogen ion transport activity | 6 | 1.83 | 3.28 | .01 |
| Cytochrome-c oxidase activity | 3 | 0.34 | 8.82 | .004 |
The table is based on the 200 best marker genes from the marker analysis of VH3-21+ versus non-VH3-21 B-CLL. O indicates observed gene number in the GO category; E, expected gene number in the GO category; R, ratio of enrichment for the GO category; and P, significance of enrichment for the GO category. Representative parent and child GO categories are shown. A detailed description of all GO categories is included as direct acyclic graphs (DAGs) in Supplemental Figure S2.
Nonsignificant GO category, but the “child” category showed significant enrichment.