Table 1. Effect of constitutive Egr-1... | American Society of Hematology

Table 1.

Effect of constitutive Egr-1 expression on M1myc leukemogenicity

	Mice dead, %				Myeloid leukemic cells recovered from BM†
Cells*	4 wk	8 wk	12 wk		Myeloid leukemic cells recovered from BM†
M1
No IL-6	63	100	—	+
With IL-6	0	0	0	-
M1Egr-1
No IL-6	0	23	100	+
With IL-6	0	0	0	-
M1myc
No IL-6	100	—	—	+
With IL-6	87	100	—	+
M1Egr-1/myc
No IL-6	53	100	—	+
With IL-6	0	0	0	-

	Mice dead, %				Myeloid leukemic cells recovered from BM†
Cells*	4 wk	8 wk	12 wk		Myeloid leukemic cells recovered from BM†
M1
No IL-6	63	100	—	+
With IL-6	0	0	0	-
M1Egr-1
No IL-6	0	23	100	+
With IL-6	0	0	0	-
M1myc
No IL-6	100	—	—	+
With IL-6	87	100	—	+
M1Egr-1/myc
No IL-6	53	100	—	+
With IL-6	0	0	0	-

Each cell type was intravenously injected into 13 nude mice. Cells were treated for 5 days with or without IL-6 (100 ng/mL) prior to inoculation into mice.

†

Three weeks following inoculation, one mouse injected with each cell type was humanely killed and the BM analyzed for the presence of myeloid leukemic cells.

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