No relation between plasma FVIII and cholesterol or triglyceride levels in mice
Mice . | No. . | Cholesterol, mean mM (68% CI) . | Triglycerides, mean mM (68% CI) . | FVIII, mean U/mL (68% CI) . |
|---|---|---|---|---|
| ApoE-/-LDLR-/-LRP- | 8 | 16.2 (11.5-22.9) | 1.0 (0.7-1.6) | 4.2 (3.3-5.5) |
| ApoE-/-LDLR-/- | 10 | 23.3 (17.6-31.0)* | 2.1 (1.4-3.1)* | 1.6 (1.4-1.8)* |
| Nontransgenic controls | 6 | 2.1 (1.9-2.2) | 0.3 (0.3-0.4) | 1.0 (0.9-1.1) |
| HuAPOCI | 6 | 19.5 (16.4-23.2)† | 36.9 (27.4-45.4)† | 0.5 (0.3-0.8)† |
Mice . | No. . | Cholesterol, mean mM (68% CI) . | Triglycerides, mean mM (68% CI) . | FVIII, mean U/mL (68% CI) . |
|---|---|---|---|---|
| ApoE-/-LDLR-/-LRP- | 8 | 16.2 (11.5-22.9) | 1.0 (0.7-1.6) | 4.2 (3.3-5.5) |
| ApoE-/-LDLR-/- | 10 | 23.3 (17.6-31.0)* | 2.1 (1.4-3.1)* | 1.6 (1.4-1.8)* |
| Nontransgenic controls | 6 | 2.1 (1.9-2.2) | 0.3 (0.3-0.4) | 1.0 (0.9-1.1) |
| HuAPOCI | 6 | 19.5 (16.4-23.2)† | 36.9 (27.4-45.4)† | 0.5 (0.3-0.8)† |
Blood was drawn from ApoE-/-LDLR-/-LRP-, ApoE-/-LDLR-/-, huAPOCI transgenic, and nontransgenic control mice. Plasma samples were analyzed for cholesterol, triglycerides, and FVIII, as described in “Materials and methods.” FVIII levels of huAPOCI transgenic and nontransgenic control mice were assayed using pooled C57BL/6J plasma as a reference, whereas those of ApoE-/-LDLR-/-LRP- and ApoE-/-LDLR-/- mice were expressed against pooled LRPflox/flox plasma. Data represent geometric mean values with 68% confidence intervals in parentheses.
P < .05, significantly different from ApoE-/-LDLR-/-LRP- mice; Mann-Whitney U test.
P < .05, significantly different from nontransgenic controls; Mann-Whitney U test.