Plasma parameters in mice that lack LRP, LDLR, or both
Plasma component . | Control . | LRP- . | LDLR-/- . | LDLR-/-LRP- . |
|---|---|---|---|---|
| FVIII, U/mL | 1.1 (0.9-1.2) | 1.8 (1.6-2.0)* | 0.9 (0.7-1.2) | 4.6 (3.7-5.6)† |
| VWF, U/mL | 1.0 (0.9-1.3) | 1.3 (1.1-1.5)* | 0.9 (0.7-1.2) | 3.3 (2.7-4.1)† |
| FV, U/mL | 1.0 (0.9-1.1) | 1.1 (1.0-1.3) | 1.1 (1.0-1.2) | 1.1 (1.0-1.2) |
| FIX, U/mL | 1.1 (0.9-1.2) | 1.0 (0.9-1.1) | 1.1 (0.9-1.3) | 1.1 (1.0-1.3) |
| TPA, U/mL | 1.8 (1.5-2.0) | 2.4 (1.9-3.1)* | 2.0 (1.8-2.1) | 2.3 (1.9-2.7) |
| Cholesterol, mM | 1.7 (1.5-1.9) | 1.7 (1.5-1.9) | 7.0 (6.1-8.1)* | 19.5 (17.2-22.3)† |
| Triglycerides, mM | 0.2 (0.1-0.3) | 0.2 (0.1-0.2) | 0.8 (0.7-1.0)* | 3.0 (2.5-3.7)† |
Plasma component . | Control . | LRP- . | LDLR-/- . | LDLR-/-LRP- . |
|---|---|---|---|---|
| FVIII, U/mL | 1.1 (0.9-1.2) | 1.8 (1.6-2.0)* | 0.9 (0.7-1.2) | 4.6 (3.7-5.6)† |
| VWF, U/mL | 1.0 (0.9-1.3) | 1.3 (1.1-1.5)* | 0.9 (0.7-1.2) | 3.3 (2.7-4.1)† |
| FV, U/mL | 1.0 (0.9-1.1) | 1.1 (1.0-1.3) | 1.1 (1.0-1.2) | 1.1 (1.0-1.2) |
| FIX, U/mL | 1.1 (0.9-1.2) | 1.0 (0.9-1.1) | 1.1 (0.9-1.3) | 1.1 (1.0-1.3) |
| TPA, U/mL | 1.8 (1.5-2.0) | 2.4 (1.9-3.1)* | 2.0 (1.8-2.1) | 2.3 (1.9-2.7) |
| Cholesterol, mM | 1.7 (1.5-1.9) | 1.7 (1.5-1.9) | 7.0 (6.1-8.1)* | 19.5 (17.2-22.3)† |
| Triglycerides, mM | 0.2 (0.1-0.3) | 0.2 (0.1-0.2) | 0.8 (0.7-1.0)* | 3.0 (2.5-3.7)† |
At 4 weeks after the final pI:pC injection, blood was drawn from control, LRP-, LDLR-/-, and LDLR-/-LRP- mice. Plasma samples were analyzed for FVIII, VWF, FV, FIX, t-PA cholesterol, and triglycerides, as described in “Materials and methods.” Data represent geometric mean values with 68% confidence intervals in parentheses. n = 12 for all groups except LDLR-/- (n = 9).
P < .05, significantly different from control mice; Mann-Whitney U test.
P < .05, significantly different from LRP-, LDLR-/-, and control mice; Mann-Whitney U test.